85588-36-9

Basic information

• Product Name: (4-chloro-3-methylphenyl)(phenyl)methanone
• Synonyms: (4-chloro-3-methylphenyl)(phenyl)methanone
• CAS NO: 85588-36-9
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.68954
• Mol File: 85588-36-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-chloro-3-methylphenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chloro-3-methylphenyl)(phenyl)methanone(85588-36-9)
• EPA Substance Registry System: (4-chloro-3-methylphenyl)(phenyl)methanone(85588-36-9)

Safety Data

• Hazardous Substances Data: 85588-36-9(Hazardous Substances Data)

Upstream product

• 21900-24-3 3-methyl-4-chloro benzoylchloride 
• 71-43-2 benzene 
• 609-65-4 o-chlorobenzoyl chloride 
• 951891-12-6 2-bromo-4'-chloro-3'-methyl-benzophenone 
• 74617-45-1 2,4'-dichloro-3'-methyl-benzophenone 
• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 110-86-1 pyridine 
• 141123-11-7 o-(4-Chloro-3-methyl)benzoyl benzoic acid 
• 7154-66-7 2-bromobenzoic acid chloride 
• 95-49-8 2-methylchlorobenzene 

Downstream Products

• 85588-39-2 3-bromomethyl-4-chlorobenzophenone 
• 85588-45-0 2-(6-chloro-3-benzoylphenyl)propionitrile 
• 85588-42-7 6-chloro-3-benzoylphenyl acetonitrile 

Relevant articles and documents

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach to generate ketones directly from broadly available carboxylic acids without the use of corrosive and reactive Lewis or Bronsted acid additives, and instead from compounds that are readily available, stable, and functional group compatible.

6-Halogen derivatives of 2-(3-benzoylphenyl)propionic acid.

The synthesis of the 6-fluoro (I a), 6-chloro (I b) and 6-bromo (I c) derivatives of the known antiinflammatory agent 2-(3-benzoylphenyl)propionic acid (ketoprofen) is reported. The procedure employed involves the direct phase-transfer methylation of the