85588-36-9

Upstream product

• 141123-11-7 o-(4-Chloro-3-methyl)benzoyl benzoic acid 
• 21900-24-3 3-methyl-4-chloro benzoylchloride 
• 71-43-2 benzene 
• 110-86-1 pyridine 
• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 95-49-8 2-methylchlorobenzene 
• 74617-45-1 2,4'-dichloro-3'-methyl-benzophenone 
• 951891-12-6 2-bromo-4'-chloro-3'-methyl-benzophenone 
• 7154-66-7 2-bromobenzoic acid chloride 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 85588-39-2 3-bromomethyl-4-chlorobenzophenone 
• 85588-45-0 2-(6-chloro-3-benzoylphenyl)propionitrile 
• 85588-42-7 6-chloro-3-benzoylphenyl acetonitrile 

Relevant academic research and scientific papers

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach to generate ketones directly from broadly available carboxylic acids without the use of corrosive and reactive Lewis or Bronsted acid additives, and instead from compounds that are readily available, stable, and functional group compatible.

Two-step one-pot synthesis method for meta-substituted diphenyl ketone compound

The invention discloses a two-step one-pot synthesis method for a meta-substituted diphenyl ketone compound. According to the method, transition metal palladium is used as a catalyst, anhydrous sodium acetate is used as an additive, aromatic acid and a benzoylformic compound are subjected to an ortho-position C-H functionalization reaction based on carboxyl groups, then by means of the synergistic effect of CuO and the additive anhydrous sodium acetate, a decarboxylation coupling reaction is directly carried out without separating products, and the meta-substituted diphenyl ketone compound is synthesized through the two-step one-pot method. The two-step one-pot synthesis method has the advantages that the raw materials are simple and easy to obtain, reaction operations are simple, the method is environmentally friendly, and the product yield is high.

6-Halogen derivatives of 2-(3-benzoylphenyl)propionic acid.

The synthesis of the 6-fluoro (I a), 6-chloro (I b) and 6-bromo (I c) derivatives of the known antiinflammatory agent 2-(3-benzoylphenyl)propionic acid (ketoprofen) is reported. The procedure employed involves the direct phase-transfer methylation of the