21900-24-3

Basic information

• Product Name: 4-Chloro-3-methylbenzoyl chloride
• Synonyms: 3-methyl-4-chlorobenzoyl chloride
• CAS NO: 21900-24-3
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.03864
• Mol File: 21900-24-3.mol
• Article Data: 8

Chemical Properties

• Appearance: Colorless to yellow/Liquid
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-Chloro-3-methylbenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-methylbenzoyl chloride(21900-24-3)
• EPA Substance Registry System: 4-Chloro-3-methylbenzoyl chloride(21900-24-3)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 21900-24-3(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-methylbenzoyl chloride is a chemical compound with the molecular formula C8H6ClO and a molar mass of 168.58 g/mol. It is a derivative of benzoyl chloride and contains a chlorine atom and a methyl group attached to the benzene ring. 4-Chloro-3-methylbenzoyl chloride is commonly used in organic synthesis as a reagent for the preparation of various derivatives and pharmaceutical intermediates. It is a highly reactive compound that can undergo various chemical reactions, including nucleophilic substitution and addition reactions. Due to its reactivity and versatility, 4-Chloro-3-methylbenzoyl chloride is an important building block in the production of various pharmaceuticals, agrochemicals, and other fine chemicals. However, it should be handled and stored with caution due to its corrosive and toxic nature.

Upstream product

• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 79-37-8 oxalyl dichloride 
• 117890-58-1 4-(bromomethyl)-1-chloro-2-methylbenzene 
• 95-66-9 2,4-dimethylchlorobenzene 

Downstream Products

• 106272-03-1 (4-chloro-3-methyl-phenyl)-cyclohex-1-enyl ketone 
• 1301215-14-4 1-isopropyl-1'-(4-chloro-3-methylbenzoyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one 
• 1207192-78-6 C₁₆H₁₄ClF₃N₂O₃S 
• 85588-45-0 2-(6-chloro-3-benzoylphenyl)propionitrile 
• 85588-42-7 6-chloro-3-benzoylphenyl acetonitrile 
• 85588-39-2 3-bromomethyl-4-chlorobenzophenone 
• 85588-36-9 (4-chloro-3-methylphenyl)(phenyl)methanone 

Relevant articles and documents

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The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C-H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C-H trifluor

Biaryl Benzylamine Derivatives

The present invention relates to biaryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.

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