21900-24-3

Usage

Uses

Used in Organic Synthesis:
4-Chloro-3-methylbenzoyl chloride is used as a reagent in organic synthesis for the preparation of various derivatives and pharmaceutical intermediates. Its reactivity allows it to participate in nucleophilic substitution and addition reactions, contributing to the creation of a wide range of chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Chloro-3-methylbenzoyl chloride is utilized as a key intermediate in the synthesis of various drugs. Its ability to form different chemical entities makes it valuable for developing new medications with specific therapeutic properties.
Used in Agrochemical Industry:
4-Chloro-3-methylbenzoyl chloride also finds application in the agrochemical industry, where it serves as a precursor for the development of pesticides and other agricultural chemicals. Its role in creating effective and targeted agrochemicals contributes to enhanced crop protection and yield.
Used in Fine Chemicals Production:
4-Chloro-3-methylbenzoyl chloride is employed in the production of fine chemicals, which are high-purity chemicals used in various industries, including fragrances, dyes, and specialty chemicals. The versatility of 4-Chloro-3-methylbenzoyl chloride in forming diverse chemical structures is crucial for the synthesis of these high-value products.
It is important to handle and store 4-Chloro-3-methylbenzoyl chloride with caution due to its corrosive and toxic nature, ensuring safety in the laboratory and industrial settings.

Upstream product

• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 95-66-9 2,4-dimethylchlorobenzene 
• 79-37-8 oxalyl dichloride 
• 117890-58-1 4-(bromomethyl)-1-chloro-2-methylbenzene 

Downstream Products

• 106272-03-1 (4-chloro-3-methyl-phenyl)-cyclohex-1-enyl ketone 
• 85588-36-9 (4-chloro-3-methylphenyl)(phenyl)methanone 
• 85588-39-2 3-bromomethyl-4-chlorobenzophenone 
• 85588-42-7 6-chloro-3-benzoylphenyl acetonitrile 
• 85588-45-0 2-(6-chloro-3-benzoylphenyl)propionitrile 
• 1207192-78-6 C₁₆H₁₄ClF₃N₂O₃S 
• 1301215-14-4 1-isopropyl-1'-(4-chloro-3-methylbenzoyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one 

Relevant academic research and scientific papers

Palladium-Catalyzed C-H Trifluoroethoxylation of N-Sulfonylbenzamides

The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C-H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C-H trifluor

N1-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions there-of; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal

Biaryl Benzylamine Derivatives

The present invention relates to biaryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Rational modification of a candidate cancer drug for use against chagas disease

Chagas disease is one of the major neglected diseases of the world. Existing drug therapies are limited, ineffective, and highly toxic. We describe a novel strategy of drug discovery of adapting an existing clinical compound with excellent pharmaceutical properties to target a pathogenic organism. The protein farnesyltransferase (PFT) inhibitor tipifarnib, now in phase III anticancer clinical trials, was previously found to kill Trypanosoma cruzi by blocking sterol 14a-demethylase (14DM). We rationally developed tipifarnib analogues that display reduced affinity for human PFT to reduce toxicity while increasing affinity for parasite 14DM. The lead compound has picomolar activity against cultured T. cruzi and is efficacious in a mouse model of acute Chagas disease.

Viral Polymerase Inhibitors

Compounds of formula I: wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

Method for treating allergies using substituted pyrazoles

A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.

Method for treating allergies using substituted pyrazoles

A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.

6-Halogen derivatives of 2-(3-benzoylphenyl)propionic acid.

The synthesis of the 6-fluoro (I a), 6-chloro (I b) and 6-bromo (I c) derivatives of the known antiinflammatory agent 2-(3-benzoylphenyl)propionic acid (ketoprofen) is reported. The procedure employed involves the direct phase-transfer methylation of the