85599-11-7

Upstream product

• 6315-52-2 1,2-bis-tosyloxyethane 
• 1061746-02-8 (2-methoxyphenyl)(phenyl)phosphane oxide 
• 20663-35-8 (S_p)-(2-methoxyphenyl)methylphenylphosphine oxide 
• 35143-99-8 (R_p)-(2-methoxyphenyl)methylphenylphosphine oxide 
• 55739-58-7 (R_P,R_P)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane 
• 107541-67-3 (2-methoxy-phenyl)-phenylphosphinic chloride 
• 20663-35-8 (2-methoxyphenyl)(methyl)(phenyl)phosphine oxide 
• 87214-08-2 C₁₇H₂₁INOP 
• 1636-14-2 bis(diethylamino)phenylphosphine 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 87214-07-1 (2R,4S,5R)-2,3,4,5-tetrahydro-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphosphole 
• 6389-79-3 (-)-(S)_p Methyl methylphenylphosphinate 
• 87214-08-2 C₁₇H₂₁INOP 
• 87248-41-7 (2S,4R,5S)-3,4-Dimethyl-2,5-diphenyl-[1,3,2]oxazaphospholidine 

Downstream Products

• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 55739-58-7 (R_P,R_P)-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane 
• 55739-58-7 (S(P),S(P))-1,2-bis[(o-anisyl)(phenyl)phosphino]ethane 
• 55739-58-7 (R,R)-1,2-Aethandiylbis<(o-methoxyphenyl)phenylphosphin> 
• 131830-91-6 (R_P,R_P)-1,2-bis[(o-anisyl)(phenyl)phosphino-P-borane]ethane 
• 1064689-42-4 (R,R)-1,2-bis[phenyl-(2-hydroxybenzene) phosphine oxide]ethane 
• 55739-58-7 (+/-)-1,2-ethandiylbis[(o-anisylphenyl)phenyl]phosphine 

Relevant academic research and scientific papers

Preparation method of chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphino] ethane

The invention discloses a preparation method of chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphino] ethane, and belongs to the field of organic synthesis. According to the method, (2-methoxyphenyl) (phenyl) phosphine oxide chloride is used as an initial raw material; 2-methoxyphenyl) (phenyl) phosphine oxide lithium is prepared from 2-methoxyphenyl and metal lithium, then the 2-methoxyphenyl) (phenyl) phosphine oxide lithium reacts with 1, 2-dibromoethane to obtain racemic 1, 2-bis [(2-methoxyphenyl) phenylphosphine oxide] ethane, chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphine oxide] ethane is obtained after chiral resolution, and finally trivalent chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphine oxide] ethane is obtained through reduction. The invention relates to 1, 2-bis [(2-methoxyphenyl) phenylphosphino] ethane. Compared with the prior art, the method has the advantages of short reaction steps, simple operation and high yield, and is more suitable for industrial production. The prepared chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphino] ethane is used as a ligand for chiral catalysis and is applied to the field of medicines.

The Trityl-Cation Mediated Phosphine Oxides Reduction

Reduction of phosphine oxides into the corresponding phosphines using PhSiH3 as a reducing agent and Ph3C+[B(C6F5)4]? as an initiator is described. The process is highly efficient, reducing a broad range of secondary and tertiary alkyl and arylphosphines, bearing various functional groups in generally good yields. The reaction is believed to proceed through the generation of a silyl cation, which reaction with the phosphine oxide provides a phosphonium salt, further reduced by the silane to afford the desired phosphine along with siloxanes. (Figure presented.).

Preparation method of chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphino] ethane

The invention discloses a preparation method of chiral 1, 2-bis [(2-methoxyphenyl) phenylphosphino] ethane, and belongs to the technical field of organic chemistry. The preparation method is carried out according to the following reaction path: the reacti

P-Chiral Phosphines Enabled by Palladium/Xiao-Phos-Catalyzed Asymmetric P-C Cross-Coupling of Secondary Phosphine Oxides and Aryl Bromides

The development of transition-metal-catalyzed methods for the synthesis of P-chiral phosphine derivatives poses a considerable challenge. Herein, we present a direct Pd/Xiao-Phos-catalyzed cross-coupling reaction of easily accessible secondary phosphine o

Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

A series of bifunctional phosphine oxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asymmetric hydrosilylation of ketimines. bis-Phosphine oxides, hydroxy-phosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide displayed the highest enantioselectivity of 60%.

Chemoselective Reduction of Phosphine Oxides by 1,3-Diphenyl-Disiloxane

Reduction of phosphine oxides to the corresponding phosphines represents the most straightforward method to prepare these valuable reagents. However, existing methods to reduce phosphine oxides suffer from inadequate chemoselectivity due to the strength of the P=O bond and/or poor atom economy. Herein, we report the discovery of the most powerful chemoselective reductant for this transformation to date, 1,3-diphenyl-disiloxane (DPDS). Additive-free DPDS selectively reduces both secondary and tertiary phosphine oxides with retention of configuration even in the presence of aldehyde, nitro, ester, α,β-unsaturated carbonyls, azocarboxylates, and cyano functional groups. Arrhenius analysis indicates that the activation barrier for reduction by DPDS is significantly lower than any previously calculated silane reduction system. Inclusion of a catalytic Br?nsted acid further reduced the activation barrier and led to the first silane-mediated reduction of acyclic phosphine oxides at room temperature.

Asymmetric synthesis of phosphinates, phosphine oxides and phosphines by Michaelis Arbuzov rearrangement of chiral oxazaphospholidine

A general approach to asymmetric synthesis of high optically active tertiary organophosphorus compounds is described.Oxazaphospholidine 3 reacts with alkyl halide to give regio and stereoselectively the corresponding phosphinamide 4.Methyl phenyl phosphin

Asymmetric catalysis

New optically active bis phosphine compounds which are useful in optically active catalysts. Such catalysts are particularly useful in catalytic asymmetric hydrogenation.