85599-84-4Relevant academic research and scientific papers
Radical Rearrangement of Aryl/Alkylidene Malononitriles via Aza Michael Addition/Decynoformylation/Addition Sequence: An Access to α-Aminonitriles and α-Aminoamides
Bhoite, Shubhangi P.,Bansode, Ajay H.,Suryavanshi, Gurunath
, p. 14858 - 14865 (2020/12/02)
An efficient, safe, and environmentally friendly tertiary butyl hydrogen peroxide (TBHP)-mediated rearrangement of aryl/alkylidene malononitrile with anilines has been developed with in situ generation of HCN as the cyanide source for the synthesis of sub
A novel approach to the synthesis of α-aminonitriles using triphenyl-phosphine dibromide under solvent-free conditions
Chaturvedi, Devdutt,Chaturvedi, Amit K.,Dwivedi, Parmesh K.,Mishra, Nisha
, p. 33 - 36 (2013/02/23)
A quick and highly efficient, one-pot, three-component, solvent-free method for the synthesis of α-aminonitriles starting from the corresponding carbonyl compounds, amines, and trimethylisocyanide using triphenylphosphine dibromide, has been developed. Diverse α-aminonitriles have been synthesized in good to excellent yields (80-99%) using a range of aldehydes, ketones and amines. Georg Thieme Verlag Stuttgart · New York.
A novel approach for the synthesis of α-aminonitriles using Mitsunobu's reagent under solvent-free conditions
Chaturvedi, Devdutt,Chaturvedi, Amit K.,Mishra, Nisha,Mishra, Virendra
, p. 5398 - 5401 (2012/10/29)
A highly efficient, one-pot, three-component, solvent-free protocol for the synthesis of α-aminonitriles starting from their corresponding carbonyl compounds, amines, using Mitsunobu's reagent has been developed. Diversity of α-aminonitriles has been synthesized in good to excellent yields (80-99%) using various kinds of aldehydes/ketones and a variety of amines.
Catalyst-free, facile, and an efficient synthesis of α-aminonitriles employing Zn(CN)2 as an ecofriendly cyanating agent
Shah, Sakshi,Singh, Baldev
experimental part, p. 151 - 156 (2012/01/19)
An efficient and eco-friendly method has been developed for the synthesis of α-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and Zn(CN)2 under mild conditions. This protocol has the features of use of inexpensive, ecofriendly readily available, effective cyanide source, high yield, and simple work-up procedure.
Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes
Cruz-Acosta, Fabio,Santos-Exposito, Alicia,De Armas, Pedro,Garcia-Tellado, Fernando
experimental part, p. 6839 - 6841 (2010/03/25)
The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dim
