85613-29-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 85613-28-1 3-[p-(2-imidazolyl)phenoxy]-1,2-propanediol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 91944-48-8 4-[(4-formylphenoxy)methyl]-2,2-dimethyl-1,3-dioxolane 
• 85613-27-0 3--1,2-propanediol acetonide 

Downstream Products

• 85613-45-2 3--1,2-epoxypropane 
• 91944-34-2 2-[[p-[3-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-hydroxypropoxy]phenyl]]imidazole 
• 85613-31-6 2-[p-(3-Cyclopropylamino-2-hydroxypropoxy)phenyl]-imidazole 

Relevant academic research and scientific papers

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.