85621-87-0

Upstream product

• 96724-73-1 N-benzyl-1-(2,4-dimethoxyphenyl)methanamine 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 83304-60-3 benzyl (2,4-dimethoxybenzyl)-amine 
• 85621-94-9 Diethyl-1-(2,4-dimethoxybenzyl)-3-(2-methyl-1,3-dioxolane-2-yl)-4-oxo-2,2-azetidine-dicarboxylate 
• 83304-64-7 diethyl 3-acetyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidine-dicarboxylate 
• 83304-63-6 1-(2,4-Dimethoxy-benzyl)-3-hydroxy-3-methyl-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 83304-61-4 diethyl(N-benzyl)-N-(2,4-dimethoxy-benzyl)-amino-malonate 
• 81902-49-0 diethyl N-(2,4-dimethoxybenzyl)-amino-malonate 
• 85621-92-7 trans ethyl 1-(2,4-dimethoxybenzyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-oxoazetidinecarboxylate 
• 85621-92-7 ethyl 1-(2,4-dimethoxybenzyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-oxoazetidinecarboxylate 

Downstream Products

• 108908-31-2 (2R,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidine-2-carbaldehyde 
• 87231-35-4 [(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile 
• 108908-36-7 p-nitrobenzyl 1-hydroxy-1-<(3RS,4SR)-4-(2,2-dimethoxyethyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-azetidin-1-yl>acetate 
• 108908-38-9 Acetic acid 1-[(2R,3R)-1-(2,4-dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-2-nitro-ethyl ester 
• 108908-32-3 (3RS,4SR)-1-(2,4-dimethoxybenzyl)-4-(1-hydroxy-2-nitroethyl)-3-(2-methyl-1,3-dioxolan-2-yl)azetidin-2-one 
• 108908-34-5 (3RS,4SR)-1-(2,4-dimethoxybenzyl)-4-(2,2-dimethoxyethyl)-3-(2-methyl-1,3-dioxolan-2-yl)azetidin-2-one 
• 108908-33-4 (3RS,4RS)-1-(2,4-dimethoxybenzyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-(2-nitroethyl)azetidin-2-one 
• 85621-90-5 (3R,4R)-1-(2,4-Dimethoxy-benzyl)-4-iodomethyl-3-(2-methyl-[1,3]dioxolan-2-yl)-azetidin-2-one 
• 85621-88-1 Methanesulfonic acid (2S,3S)-1-(2,4-dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-ylmethyl ester 

Relevant academic research and scientific papers

SIMPLE AND CONDENSED β-LACTAMS-I. THE APPLICATION OF DIKETENE IN β-LACTAM SYNTHESIS. THE SYNTHESIS AND FUNCTIONAL GROUP MANIPULATIONS OF DIETHYL 3-ACETYL-4-OXOAZETIDINE-2,2-DICARBOXYLATES

Acetylation of the N-substituted diethyl aminomalonates 3a-3d with diketene furnished the ring tautomers 6a-6d of the expected acetoacetyl derivatives 5.By treatment with iodine and sodium ethoxide compounds 6a-6d are smoothly converted into the β-lactam