85628-47-3

Basic information

• Product Name: 1-methoxy-4-(2-methyl-2-nitropropyl)benzene
• Synonyms: 1-methoxy-4-(2-methyl-2-nitropropyl)benzene
• CAS NO: 85628-47-3
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• EINECS: -0
• Mol File: 85628-47-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Solubility: Chloroform, DCM, Ethyl Acetate, Methanol
• CAS DataBase Reference: 1-methoxy-4-(2-methyl-2-nitropropyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-4-(2-methyl-2-nitropropyl)benzene(85628-47-3)
• EPA Substance Registry System: 1-methoxy-4-(2-methyl-2-nitropropyl)benzene(85628-47-3)

Safety Data

• Hazardous Substances Data: 85628-47-3(Hazardous Substances Data)

Usage

Uses

1-Methoxy-4-(2-methyl-2-nitropropyl)benzene is an substituent in the synthesis of Olodaterol (O262000), a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy.

Upstream product

• 16066-97-0 1-nitro-1,1-dimethyl-2-(4-hydroxyphenyl]ethane 
• 74-88-4 methyl iodide 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 56490-94-9 1-(2-amino-2-methylpropyl)-4-methoxybenzene 
• 926319-48-4 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride 
• 869477-96-3 Olodaterol hydrochloride 
• 56490-93-8 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride 
• 1401436-45-0 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine 

Relevant articles and documents

IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE

The present invention provides an improved process for the manufacture (R)-6- hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4- benzoxazin-3(4H)-one, in high purity and high yield, through the use of 1,1-dimethyl-2- (4-met

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