85628-47-3

Usage

Uses

Used in Pharmaceutical Industry:
1-methoxy-4-(2-methyl-2-nitropropyl)benzene is used as a substituent in the synthesis of Olodaterol (O262000), a novel inhaled β2-adrenoceptor agonist with a 24-hour bronchodilatory efficacy. This makes it a valuable component in the development of treatments for respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Upstream product

• 16066-97-0 1-nitro-1,1-dimethyl-2-(4-hydroxyphenyl]ethane 
• 77-78-1 dimethyl sulfate 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 74-88-4 methyl iodide 

Downstream Products

• 56490-94-9 1-(2-amino-2-methylpropyl)-4-methoxybenzene 
• 1401436-45-0 4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)-6-morpholino-1,3,5-triazin-2-amine 
• 926319-48-4 6-(phenylmethoxy)-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride 
• 869477-96-3 Olodaterol hydrochloride 
• 56490-93-8 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine hydrochloride 

Relevant academic research and scientific papers

IMPROVED PROCESS FOR THE MANUFACTURE OF R-6-HYDROXY-8-[1-HYDROXY-2-[2-(4-METHOXYPHENYL)-1,1-DIMETHYLETHYLAMINOETHYL]-2H-1,4-BENZOXAZIN-3(4H)-ONE HYDROCHLORIDE

The present invention provides an improved process for the manufacture (R)-6- hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4- benzoxazin-3(4H)-one, in high purity and high yield, through the use of 1,1-dimethyl-2- (4-met

(ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

Provided herein are (alpha-substituted aralkylamino or heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula 1, and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases

Methods and compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.