856414-36-3

Basic information

• Product Name: Benzoic acid, 2-(azidocarbonyl)-3-nitro-, methyl ester
• CAS NO: 856414-36-3
• Molecular Formula: C9H6N4O5
• Molecular Weight: 250.17
• Mol File: 856414-36-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(azidocarbonyl)-3-nitro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(azidocarbonyl)-3-nitro-, methyl ester(856414-36-3)
• EPA Substance Registry System: Benzoic acid, 2-(azidocarbonyl)-3-nitro-, methyl ester(856414-36-3)

Safety Data

• Hazardous Substances Data: 856414-36-3(Hazardous Substances Data)

Upstream product

• 21606-04-2 methyl 2-carboxy-3-nitrobenzoate 
• 541-41-3 chloroformic acid ethyl ester 
• 13365-26-9 dimethyl 3-nitrophthalate 
• 73833-13-3 acid chloride of 1-methylhydrogen-3-nitrophthalate 
• 603-11-2 3-nitrophthalic acid 

Downstream Products

• 150058-27-8 2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 57113-91-4 methyl 3-nitroanthranilate 
• 139481-59-7 candesartan 
• 139482-06-7 3-[2'-(1H-Tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2,2,2-trifluoro-ethoxy)-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-97-3 2-Morpholin-4-yl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-98-4 2-Piperidin-1-yl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-96-2 2-Butylamino-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 150058-11-0 4'-{[tert-Butoxycarbonyl-(2-methoxycarbonyl-6-nitro-phenyl)-amino]-methyl}-biphenyl-2-carboxylic acid methyl ester 
• 136284-88-3 2-Ethylsulfanylmethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-71-3 2-Propylamino-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-65-5 2-Propylsulfanyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-60-0 ethyl 2-Propoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 136285-07-9 Methyl 2-(2-methylthioethyl)-1-[[2'-(1H-tetrazol-5-yl]biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 

Relevant articles and documents

A 2 - ethoxy benzimidazole - 7 - carboxylic acid methyl ester

The invention discloses a synthesis method of 2-ethoxy benzimidazole-7-carboxylic acid methyl ester. The problem that an existing process is not high in content and is very low in yield is solved. According to the synthesis method, 3-nitryl phthalic acid is used as a raw material, rearrangement is performed in a water solution after methyl esterification, acylation and re-nitridation, then tin powder is adopted to perform reduction and loop closing so as to obtain the 2-ethoxy benzimidazole-7-carboxylic acid methyl ester. By the adoption of the synthesis method, produced impurities are very little, the content is high, and the yield is also high.

METHOD FOR PRODUCTION OF CANDESARTAN

The invention relates to novel methods for the production of Candesartan, or a protected form of Candesartan, a Candesartan salt or ester, compounds of application in said method, methods for production thereof, use thereof in said method, a novel polymorph of Candesartan cilexetil, a method for production and use thereof for production of a medicament.

A convenient synthesis of 5- and 8-nitroquinazoline-2,4-dione derivatives

3-Nitrophthalic acid 1 was converted selectively to the two regioisomeric monoesters 2 and 3, which were subsequently transformed via Curtius rearrangement to the corresponding 5- and 8-nitroquinazoline-2,4-diones 4 and 5, respectively. The reduction of t