856414-68-1

Usage

Uses

Used in Pharmaceutical Industry:
3-OXO-3-(TETRAHYDRO-PYRAN-4-YL)-PROPIONIC ACID ETHYL ESTER is used as a building block for the synthesis of pharmaceutical drugs, specifically for the production of anti-inflammatory and analgesic medications. Its chemical structure allows for the creation of compounds that can effectively address inflammation and pain.
Used in Fragrance and Flavor Industry:
3-OXO-3-(TETRAHYDRO-PYRAN-4-YL)-PROPIONIC ACID ETHYL ESTER is also used in the synthesis of fragrances and flavor compounds, where its unique chemical properties contribute to the development of various scents and tastes in consumer products.
Used in Medicinal and Therapeutic Research:
3-OXO-3-(TETRAHYDRO-PYRAN-4-YL)-PROPIONIC ACID ETHYL ESTER is being studied for its potential medicinal and therapeutic properties, with ongoing research exploring its biological activity and possible applications in healthcare and medicine.

Upstream product

• 137052-08-5 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one 
• 105-58-8 Diethyl carbonate 
• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 141-78-6 ethyl acetate 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 6148-64-7 ethyl potassium malonate 

Relevant academic research and scientific papers

METHOD OF MAKING AZAINDAZOLE DERIVATIVES

Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.

CHEMICAL COMPOUNDS

The invention is directed to to substituted indazole derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 - R6 and X are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of disorders characterized by constitutively activated ACG kinases such as cancer and more specifically leukemia and cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

PROCESSES FOR PRODUCING ALKYL 3-(4-TETRAHYDROPYRANYL)-3-OXOPROPIONATE COMPOUND AND 4-ACYLTETRAHYDROPYRAN

The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.