856438-23-8Relevant academic research and scientific papers
Stable attachment of the HMB-linker to continuous cellulose membranes for parallel solid phase spot synthesis
Volkmer-Engert, Rudolf,Hoffmann, Berit,Schneider-Mergener, Jens
, p. 1029 - 1032 (1997)
Peptides and other oligomeric molecules were prepared on continuous cellulose membranes using a stably attached p-hydroxymethyl-benzoic acid (HMB) linker. After attachment of N-protected 1,2-epoxy-propylamine to the support via an ether bond, the HMB link
N-Urethane protection of amines and amino acids in an ionic liquid
Di Gioia,Gagliardi,Leggio,Leotta,Romio,Liguori
, p. 63407 - 63420 (2015/08/11)
An efficient, solvent-free protocol for the N-fluorenylmethoxycarbonylation and N-benzyloxycarbonylation of amines is described. The reaction of aliphatic and aromatic amines with FmocOSu and Cbz-Osu in [Bmim][BF4] at room temperature afforded the corresponding N-urethane derivatives in excellent yields and do not require any further purification. The method has been extended to the N-Fmoc and N-Cbz protection of amino acids. Absence of bases, very short reaction times, high yields, selectivity and ease of product separation are some advantages of this protocol.
NHC-Cu-catalyzed addition of propargylboron reagents to phosphinoylimines. Enantioselective synthesis of trimethylsilyl-substituted homoallenylamides and application to the synthesis of S-(-)-cyclooroidin
Mszar, Nicholas W.,Haeffner, Fredrik,Hoveyda, Amir H.
supporting information, p. 3362 - 3365 (2014/03/21)
A catalytic method for the efficient and enantioselective addition of a 1-trimethylsilyl-substituted allene moiety to phosphinoylimines is presented. Transformations are promoted by 5.0 mol % of a copper complex of an N-heterocyclic carbene in the presenc
Total synthesis of Oxazolomycin a
Eto, Kohei,Yoshino, Madoka,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi
supporting information; experimental part, p. 5398 - 5401 (2011/12/04)
The first total synthesis of oxazolomycin A, a structurally novel oxazole polyene γ-lactam/β-lactone antibiotic, is described. Key features include the stereocontrolled construction of the right-hand heterocyclic core bytaking advantage of an In(III)-cata
