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Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxy-3-Nitrotoluene is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Ethoxy-3-Nitrotoluene serves as an intermediate in the production of various agrochemicals. Its role in this sector is crucial for the development of effective pesticides and other agricultural chemicals.
Used in Dye Industry:
4-Ethoxy-3-Nitrotoluene is also utilized as an intermediate in the synthesis of dyes. Its chemical properties make it suitable for creating a wide range of colors and pigments used in various applications, including textiles, plastics, and printing inks.

Upstream product

• 64-67-5 diethyl sulfate 
• 119-33-5 4-methyl-2-nitrophenol 
• 622-60-6 1-ethoxy-4-methylbenzene 
• 74-96-4 ethyl bromide 
• 75-03-6 ethyl iodide 
• 78-10-4 tetraethoxy orthosilicate 
• 1225036-72-5 potassium 4-methyl-2-nitrobenzoate 

Downstream Products

• 23385-48-0 5-Methyl-2-aethoxy-thiophenol 
• 6331-70-0 2-ethoxy-5-methylaniline 

Relevant academic research and scientific papers

Copper-mediated ortho-nitration of (hetero)arenecarboxylates

Various (hetero)arenecarboxylic acids were converted to the corresponding Daugulis amides and nitrated selectively in the ortho-position in the presence of [CuNO3(PPh3)2] and AgNO2 at 50 °C. A microwave-assisted saponification allows regenerating the carboxylate group within minutes, which may then be removed tracelessly by protodecarboxylation, or substituted by aryl- or alkoxy-groups via decarboxylative cross-coupling.

UREA DERIVATIVE

The present invention relates to a urea derivative or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect. A urea derivative having the formula: [wherein R 1 is a C 6 -C 10 aryl group which may be independently mono- to pentasubstituted by a group selected from Substituent Group a or others; R 2 is a C 6 -C 10 aryl group which may be independently mono- to pentasubstituted by a group selected from Substituent Group a or others; E is a group having the formula (II) or the formula (III) (wherein R 3 is a hydrogen atom or others; R 4 and R 5 , which are the same or different, are a hydrogen atom or others; X and U, which are the same or different, are a group represented by the formula CH or others; m and n, which are the same or different, are 1 or another number) or others; and A is a group represented by the formula -NH-C(=O)- or others], or a pharmacologically acceptable salt thereof.

Nighttime tropospheric chemistry: Kinetics and product studies in the reaction of 4-Alkyl- and 4-Alkoxytoluenes with NO3 in gas phase

Alkylbenzenes are important constituents of gasoline and industrial solvents and contribute to the formation of tropospheric ozone. The removal of these compounds from the troposphere is due to reaction with OH during the day and with NO3 during the night. Five para-substituted toluenes are reacted with the nitrate radical in gas phase. Samples to be used for product analysis were preconcentrated and analyzed by GC-MSD analysis with the use of a reference curve. The yields of methanol, ethanol, and formaldehyde were determined by FTIR analysis of the reaction mixture in the chamber. Carbonyl compounds, benzyl alcohols, and nitroderivatives were formed. In the case of the alkoxytoluenes, products were also an alkanol, benzyl alcohols, and nitrophenols. Indirect rate constants measurements were performed by comparing by FTIR measurements the decay of the aromatic compound under investigation to that of a reference compound, with a known rate constant for the reaction with NO3 added to the gas mixture. Wall loss constants were evaluated by FTIR. A Hammett correlation with ρ = - 4.3 ± 0.6; r2-= 0.87 was obtained. This and the kinetic isotope effect of 1.5-1.8 suggest a reaction mechanism occurring via an addition-elimination pathway.