85656-64-0

Basic information

• Product Name: 8-Quinolinamine,5-methyl-(9CI)
• Synonyms: 8-Quinolinamine,5-methyl-(9CI);5-Methylquinolin-8-amine;8-QuinolinaMine,5-Methyl;5-Methyl-8-quinolinamine
• CAS NO: 85656-64-0
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Product Categories: ISOQUINOLINE;organic building block
• Mol File: 85656-64-0.mol

Chemical Properties

• Melting Point: 46-47 °C
• Boiling Point: 327.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.169±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.34±0.12(Predicted)
• CAS DataBase Reference: 8-Quinolinamine,5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Quinolinamine,5-methyl-(9CI)(85656-64-0)
• EPA Substance Registry System: 8-Quinolinamine,5-methyl-(9CI)(85656-64-0)

Safety Data

• Hazardous Substances Data: 85656-64-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Quinolinamine,5-methyl-(9CI) is used as a chemical intermediate for the synthesis of various drugs. Its unique structure and properties make it a valuable component in the development of new pharmaceutical compounds.
Used in Material Science:
8-Quinolinamine,5-methyl-(9CI) has potential applications in the field of material science, where its unique properties can be utilized to create new materials with specific characteristics.
Used in Organic Synthesis:
8-Quinolinamine,5-methyl-(9CI) is also used in organic synthesis, where it can serve as a building block for the creation of more complex organic molecules.

Upstream product

• 7418-36-2 N-(5-methyl-2-nitrophenyl)acetamide 
• 578-46-1 5-methyl-2-nitroaniline 
• 7661-55-4 5-methylquinoline 
• 65745-69-9 5-methyl-8-nitroquinoline 

Downstream Products

• 85656-77-5 2,4,6-Trimethyl-benzenesulfonate1-amino-8-formylamino-5-methyl-quinolinium; 

Relevant articles and documents

Auxiliary-Directed C(sp3)?H Arylation by Synergistic Photoredox and Palladium Catalysis

Herein we describe the auxiliary-directed arylation of unactivated C(sp3)?H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site-selective arylation of aliphatic amides with α-quaternary centres is achieved with high selectivity for β-methyl C(sp3)?H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.

A First Example of Cobalt-Catalyzed Remote C H Functionalization of 8-Aminoquinolines Operating through a Single Electron Transfer Mechanism

The development of new C H functionalization protocols based on inexpensive cobalt catalysts is currently attracting significant interest. Functionalized 8-aminoquinoline compounds are high-potential building blocks in organic chemistry and pharmaceutical compounds and new facile routes for their preparation would be highly valuable. Recently, copper has been applied as catalyst for the functionalization of 8-aminoquinoline compounds and found to operate through a single electron transfer (SET) mechanism, although requiring elevated reaction temperatures. Herein, we described the first example of a cobalt-catalyzed remote C H functionalization of 8-aminoquinoline compounds operating through a SET mechanism, exemplified using a practical and mild nitration protocol. The reaction uses inexpensive cobalt nitrate hexahydrate [Co(NO3)2?6 H2O] as catalyst and tert-butyl nitrite (TBN) as nitro source. This methodology offers the basis for the facile preparation of many new functionalized 8-aminoquinoline derivatives. (Figure presented.).

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

Synthesis and Some Properties of A New Class of Six Membered Heteroaromatic Betains, 3H-Pyridobenzotriazin-4-ylium-3-ides

A series of 3H-pyridobenzotriazin-4-ylium-3-ides has been synthesised by reaction of 8-acylaminoquinolines with O-mesitylenesulphonylhydroxylamine followed by treatment with aqueous alkali.The spectral (u.v., 1H n.m.r., and 13C n.m.r. spectra) and chemical properties (bromination and 1,3-dipolar cycloaddition) of the new mesomeric betains have been investigated.