85660-18-0

Upstream product

• 100-51-6 benzyl alcohol 
• 6261-32-1 (E)-2-benzylidene-1-tetralone 
• 17356-08-0 thiourea 
• 17216-08-9 2-acetyl-1-tetralone 
• 100-52-7 benzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 6261-32-1 2-benzylidene-1-tetralone 

Downstream Products

• 85660-20-4 2-Ethylsulfanyl-4-phenyl-3,4,5,6-tetrahydro-benzo[h]quinazoline; hydrobromide 
• 3977-31-9 4-phenyl-3,4,5,6-tetrahydrobenzoquinazoline-2(1H)one 
• 85660-21-5 2-methylmercapto-4-phenyl-3,4,5,6-tetrahydrobenzoquinazoline 
• 85660-25-9 2-methylmercapto-4-phenylbenzoquinazoline 
• 85660-26-0 2-Ethylsulfanyl-4-phenyl-benzo[h]quinazoline 
• 85660-23-7 2-Methylsulfanyl-4-phenyl-5,6-dihydro-benzo[h]quinazoline 
• 85660-24-8 2-Ethylsulfanyl-4-phenyl-5,6-dihydro-benzo[h]quinazoline 
• 85660-22-6 2-Ethylsulfanyl-4-phenyl-3,4,5,6-tetrahydro-benzo[h]quinazoline 
• 1440807-79-3 C₂₀H₁₈N₂OS 
• 1141934-87-3 (E)-10-(4-chlorobenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 
• 1628798-83-3 2-(7-phenyl-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-9-yl)-3H-benzo[f]chromen-3-one 
• 1628798-76-4 3-(7-phenyl-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-9-yl)-2H-chromen-2-one 
• 1628798-72-0 9-(4-bromophenyl)-7-phenyl-6,7-dihydro-5H-benzo[h]thiazolo-[2,3-b]quinazoline 
• 1628798-67-3 9-(4-chlorophenyl)-7-phenyl-6,7-dihydro-5H-benzo[h]thiazolo-[2,3-b]quinazoline 

Relevant academic research and scientific papers

Aerobic oxidation of alcohols enabled by nitrogen-doped copper nanoparticle catalysts

Heterogeneous nitrogen-doped carbon-incarcerated copper nanoparticle catalysts have been developed. The catalysts promoted the oxidation of alcohols to the corresponding aldehydes, including aliphatic substrates, in high yield in the presence of an N-oxyl

Green chemistry preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives using HSBM technique over ZnAl2o4 nano-powders

Aim and Objective: The aim of this paper is to introduce HSBM as a green and environmentally friendly technique for the synthesis of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives over ZnAl2O4 nanopowders

Base-mediated one-pot synthesis of 3,4,5,6-tetrahydro-4-substituted benzo[h]quinazoline-2(1H)-thione derivatives and evaluation of their antioxidant activity

One-pot three-component Beginelli-like reactions of a ketone 1, an aryl aldehyde 2, and thiourea 3 in the presence of sodium hydroxide are described. In this reaction, 3,4,5,6-tertrahydro-4-substituted quinazoline-2(1H)-thione derivatives 4a–h were obtain

FeCl3·6H2O/TMSBr-catalyzed rapid synthesis of dihydropyrimidinones and dihydropyrimidinethiones under microwave irradiation

An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3 6H2O TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.

Benzoic acid compound and use thereof

The invention relates to a benzoic acid compound and a use thereof. The benzoic acid compound has a structure shown in the general formula (I) and can be used for treating the hand-foot-mouth disease caused by enterovirus 71 (EV71).

Preparation system and preparation method of benzo quinazolinone derivative

The invention discloses a preparation system and preparation method of a benzo quinazolinone derivative and belongs to the technical field of organic synthesis. The preparation system of the benzo quinazolinone derivative comprises a reactor, an ultrasonic-assisted reaction device, an ice-water bath cooling device, a suction filtration device, a washing device and a vacuum drying device, wherein the ultrasonic-assisted reaction device, the ice-water bath cooling device, the suction filtration device, the washing device and the vacuum drying device are sequentially arranged. Aromatic aldehyde, alpha-tetralone and urea or thiourea are taken as reaction raw materials and are catalyzed under the catalytic action of an acidic ionic liquid catalyst and under the ultrasonic-assisted action to prepare the benzo quinazolinone derivative. By adopting the technical scheme, the catalyst is relatively small in dosage and loss, and can be recycled for multiple times, the preparation system is high in raw material utilization rate and short in reaction time and a product is simple and convenient to purify.

PEG-SANM nanocomposite: A new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions

A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting

Benzo[h]thiazolo[2,3-b]quinazolines by an efficient p-toluenesulfonic acid-catalyzed one-pot two-step tandem reaction

A highly efficient method has been developed for synthesis of 7,9-disubstituted-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolines via multicomponent one-pot two-step tandem reaction involving 1-tetralone, arylaldehydes, thiourea, and 4-chlorophenacyl bromide/(3-bromoacetyl)coumarin utilizing p-toluenesulfonic acid as catalyst in glacial acetic acid under reflux conditions. Analytically pure products are formed with excellent yield and short reaction time. All the synthesized compounds were confirmed by their spectral and elemental analyses. Graphical abstract: [Figure not available: see fulltext.]

Synthesis, characterization and biological evaluation of fused thiazolo[3,2-a]pyrimidine derivatives

A series of fused thiazolo[3,2-a]pyrimidines (7a-g, 8a-f, 11a-g and 12a,b) have been synthesized in good yields by reaction of fused 3,4-dihydropyrimidin- 2(1H)-thiones (4a-g) with phenacyl bromides (5,6)/3-(2-bromoacetyl)coumarins (9,10) under conventional heating in acetic acid. Analytical and spectral studies as well as single crystal X-ray diffraction data on the representative compound 8e confirmed the structure of all the reaction products. All the synthesized compounds were screened for their antibacterial, antioxidant and DNA cleavage activities. The compound 7e against Escherichia coli, 8a and 8c-e against Pseudomonas aeruginosa have shown prominent antibacterial activity compared to the standard drug Penicillin with MIC 9.375 μg mL-1, whereas the compounds 11c, 12a and 12b have shown very good antioxidant activity compared to the standard drug Trolox with IC50 values 12.36, 11.12 and 13.88 μM respectively. Compounds 11f and 12b have completely cleaved the DNA even at 50 μg mL-1 concentration and the remaining compounds have partially cleaved the DNA.

Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks

2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-yl)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products.