153258-17-4

Upstream product

• 85660-18-0 3,4,6,7-tetrahydro-4-phenylbenzoquinazolin-2(1H)-thione 
• 79-11-8 chloroacetic acid 
• 100-52-7 benzaldehyde 
• 6261-32-1 2-benzylidene-1-tetralone 
• 17216-08-9 2-acetyl-1-tetralone 
• 17356-08-0 thiourea 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 79-04-9 chloroacetyl chloride 
• 3028-02-2 N-benzothiazol-2-yl-2-chloroacetamide 
• 587-65-5 N-chloroacetyl-aniline 

Downstream Products

• 1222376-96-6 (Z)-3-(5-((9-oxo-7-phenyl-5H-benzo[h]thiazolo[2,3-b]quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)benzoic acid 
• 1141934-87-3 (E)-10-(4-chlorobenzylidene)-7-phenyl-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 

Relevant academic research and scientific papers

X-ray, NMR and DFT studies on benzo[h]thiazolo[2,3-b]quinazoline derivatives

4-Phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione 3, obtained by the condensation of 2-Benzylidene-3,4-dihydronapthalen-1(2H)-one 2 with thiourea, on reaction with chloroacetic acid and 1,2-dibromoethane furnish compounds 4 and 5 and not their p

Benzoic acid compound and use thereof

The invention relates to a benzoic acid compound and a use thereof. The benzoic acid compound has a structure shown in the general formula (I) and can be used for treating the hand-foot-mouth disease caused by enterovirus 71 (EV71).

Recyclable task-specific acidic ionic liquid [NMP]H2PO4: Microwave-assisted, efficient one-pot, two-step tandem synthesis of fused thiazolo[2,3-b]quinazolinone and thiazolo[2,3-b]quinazoline derivatives

A novel, time-effective, eco-conscious and microwave-assisted tandem one-pot, two-step reaction has been described for the synthesis of thiazolo[2,3-b]quinazolinone (4a-f) and thiazolo[2,3-b]quinazoline (5a-t) derivatives in quantitative yield in the pres

Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks

2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-yl)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products.

Design, synthesis, and interaction study of quinazoline-2(1 H)-thione derivatives as novel potential Bcl-xL inhibitors

Development of inhibitors to antagonize the activities of antiapoptotic Bcl-2 family proteins is of particular interest in cancer chemotherapy. We discovered a quinazoline-2(1H)-thione derivative (DCBL55) as a new Bcl-x L, Bcl-2, and Mcl-1 inhi

Heterocyclic systems containing bridgehead nitrogen atom: Part LXXIV - Reaction of 4-phenyl-3,4,5,6-tetrahydrobenzoquinazoline-2(1H)-thione with α-haloacids and dibromoethane

4-Phenyl-3,4,5,6-tetrahydrobenzoquinazoline-2(1H)-thione(II), obtained by the condensation of 2-benzylidene-tetraline-1-one(I) with thiourea, on reaction with chloroacetic acid, α-bromopropionic acid and 1,2-dibromoethane furnishes compounds III, IV an