856667-79-3

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl-, ethyl ester
• CAS NO: 856667-79-3
• Molecular Formula: C24H21FN6O2
• Molecular Weight: 444.468
• Mol File: 856667-79-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl-, ethyl ester(856667-79-3)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl-, ethyl ester(856667-79-3)

Safety Data

• Hazardous Substances Data: 856667-79-3(Hazardous Substances Data)

Usage

General Description

Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl, ethyl ester is a chemical compound that belongs to the pyrrolo[2,1-f][1,2,4]triazine class. It is a methylated ethyl ester derivative and contains a carboxylic acid group and an indazol-5-ylamino group, as well as a fluorophenylmethyl group. Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methyl-, ethyl ester may have potential biological activities and may be used for research and development purposes in the pharmaceutical industry. Its structure and properties make it a promising candidate for the development of novel therapeutic agents.

Upstream product

• 427878-70-4 ethyl 4-hydroxy-5-methylpyrrolo[2,1-f ][1,2,4]-triazine-6-carboxylate 
• 5401-94-5 5-nitroindazole 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 529508-58-5 1-(3-fluorobenzyl)-5-nitro-1H-carbazole 
• 427878-41-9 4-chloro-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester 
• 202197-31-7 1-(3-fluorobenzyl)-1H-indazol-5-ylamine 

Downstream Products

• 856667-80-6 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 

Relevant articles and documents

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

Pyrrolotriazine-5-carboxylate ester inhibitors of EGFR and HER2 protein tyrosine kinases and a novel one-pot synthesis of C-4 subsitituted pyrrole-2,3-dicarboxylate diesters

Pyrrolotriazines with an ester group at C-5 were prepared and evaluated as inhibitors of the EGFR and HER2 receptor tyrosine kinases, validated targets for cancer therapy. The C-5 ester (15) was at least as potent as its C-6 ester analogue (17), an exampl