856694-88-7Relevant articles and documents
Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists
Dzierba, Carolyn D.,Takvorian, Amy G.,Rafalski, Maria,Kasireddy-Polam, Padmaja,Wong, Harvey,Molski, Thaddeus F.,Zhang, Ge,Li, Yu-Wen,Lelas, Snjezana,Peng, Yong,McElroy, John F.,Zaczek, Robert C.,Taub, Rebecca A.,Combs, Andrew P.,Gilligan, Paul J.,Trainor, George L.
, p. 5783 - 5790 (2007/10/03)
Corticotropin releasing factor (CRF) is the primary regulator of the hypothalamus-pituitary-adrenal (HPA) axis, coordinating the endocrine, behavioral, and autonomic responses to stress. It has been postulated that small molecules that can antagonize the