85678-83-7

Basic information

• Product Name: 5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-5-one
• Synonyms: 5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-5-one
• CAS NO: 85678-83-7
• Molecular Formula: C9H5N3OS
• Molecular Weight: 203.2205
• Mol File: 85678-83-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-5-one(85678-83-7)
• EPA Substance Registry System: 5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-5-one(85678-83-7)

Safety Data

• Hazardous Substances Data: 85678-83-7(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 85678-90-6 N-(1,3-Thiazol-2-yl)-2-chloropyridine-3-carboxamide 
• 2942-59-8 2-chloronicotinic acid 

Relevant articles and documents

Synthesis and diuretic activity of pyrido[2,3-d]pyrimidones and related compounds

The synthesis of a series of pyrido[2,3-d]pyrimidine-4-one derivatives (7) and the results of a study of their potassium-sparing diuretic activity are described. Compounds 7 were prepared from 2-chloro-3-pyridinecarbonyl chloride, 1,2-dihydro-2-thioxo-3-pyridinecarbonyl chloride, 2-methylthio-3-pyridinecarbonyl chloride or 2-(p-chlorophenyl)thio-3-pyridinecarbonylchloride and different amines through the respective amides (4). Compounds 4 and 7 were assayed for diuretic and potassium-sparing activities. Although some of the compounds showed significant diuretic activity, a significant increase of the Na+/K+ index was only observed with 5-oxo-5H(1,3)thiazolo[3,2-a]pyrido[3,2-e]pyrimidine.