85686-11-9

Upstream product

• 124-38-9 carbon dioxide 
• 20744-02-9 p-Isopropoxyphenyl methyl ether 
• 2150-46-1 Methyl 2,5-dihydroxybenzoate 
• 61227-25-6 2-methoxy-5-hydroxybenzoic acid 
• 509074-76-4 methyl 2-methoxy-5-(toluene-p-sulfonyloxy)benzoate 
• 509074-77-5 isopropyl 5-isopropoxy-2-methoxybenzoate 

Downstream Products

• 478705-41-8 5-isopropyl-2-methoxybenzoic acid 2,6-di-tert-butyl-4-methoxyphenyl ester 
• 478705-43-0 2,6-di-tert-butyl-4-methoxyphenyl 4-isopropoxy-2'-methoxy-4'-methoxymethoxy-6'-methylbiphenyl-2-carboxylate 

Relevant academic research and scientific papers

Synthesis, resolution, and absolute stereochemistry of (-)-blestriarene C

A naturally occurring 1,1′-biphenanthrene, blestriarene C (1), was prepared in 13 steps and 30% overall yield. The key steps are the ester-mediated nucleophilic aromatic substitution on 2,6-ditert-butyl-4-methoxyphenyl 5-isopropoxy-2-methoxybenzoate (4) b

STERIC EFFECTS IN THE METALLATION OF ALKOXY- AND DIALKOXY-BENZENES

With the aim of examining the role of steric factors in determining the position of metallation, the reaction of n-butyllithium with a series of 1,2-dialkoxy-, 1,2-alkylthio-, 1,4-dialkoxy-, and 2-t-butyl-1-alkoxy-benzenes has been studied in the presence and in the absence of N,N,N',N'-tetramethylethylenediamine (TMEDA).Steric factors are particularly relevant in the case of 2-t-butyl-alkoxybenzenes where the yields of metallation dramatically decrease passing from the methoxy to the isopropoxy derivative, while with the t-butoxy derivative only cleavage of the ether bond occurs.