85690-51-3Relevant academic research and scientific papers
COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION
-
, (2018/10/19)
Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods.
Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine
Díaz, Jimena E.,Ranieri, Silvia,Gruber, Nadia,Orelli, Liliana R.
supporting information, p. 1470 - 1477 (2017/08/02)
A straightforward strategy for the synthesis of dihydroquinazolines is presented, which allows for the preparation of 3,4- and 1,4-dihydroquinazolines with different substitution patterns from 2-aminobenzylamine (2-ABA) as common precursor. The required functionalization of both amino groups present in 2-ABA was achieved by different routes involving selective N-acylation and cesium carbonate-mediated N-alkylation reactions, avoiding protection/deprotection steps. The heterocycles were efficiently synthesized in short reaction times by microwave-assisted ring closure of the corresponding aminoamides promoted by ethyl polyphosphate (PPE).
General, Mild, and Metal-Free Synthesis of Phenyl Selenoesters from Anhydrides and Their Use in Peptide Synthesis
Temperini, Andrea,Piazzolla, Francesca,Minuti, Lucio,Curini, Massimo,Siciliano, Carlo
, p. 4588 - 4603 (2017/05/12)
A mild, practical, and simple procedure for phenyl selenoesters synthesis from several anhydrides and diphenyl diselenide was developed. This transition-metal-free method provides a straightforward entry to storable Fmoc-amino acid selenoesters which are effective chemoselective acylating reagents. An application to oligopeptide synthesis was illustrated.
Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation
Camacho, M. Encarnación,Chayah, Mariem,García, M. Esther,Fernández-Sáez, Nerea,Arias, Fabio,Gallo, Miguel A.,Carrión, M. Dora
, p. 638 - 650 (2016/08/27)
The synthesis of different compounds with a quinazolinone, quinazolinthione, or quinazolinimine skeleton and their in vitro biological evaluation as inhibitors of inducible and neuronal nitric oxide synthase (iNOS and nNOS) isoforms are described. These d
Isopropenyl acetate, a remarkable, cheap and acylating agent of amines under solvent- and catalyst-free conditions: A systematic investigation
Pelagalli, Romina,Chiarotto, Isabella,Feroci, Marta,Vecchio, Stefano
supporting information; experimental part, p. 2251 - 2255 (2012/09/08)
Isopropenyl acetate was proved to be an efficient reagent for acetylation of amine in the absence of solvent and catalyst. The corresponding acetamides were obtained in very high yields without any purification.
STUDIES ON 4-QUINAZOLINONES. PART IX. RANEY NICKEL DESULPHURISATION OF 4-THIOQUINAZOLINES: ALUMINA CATALYSED HYDRATION OF 1,4- AND 3,4-DIHYDROQUINAZOLINES
Chakrabarty, Manas,Chakravarty, Ajit K.,Pakrashi, Satyesh C.
, p. 445 - 450 (2007/10/02)
A number of 2-substituted 3,4-dihydroquinazolines and 1,2-disubstituted 1,4-dihydroquinazolines but not the 3-mono or 2,3-disubstituted derivatives, prepared by Raney nickel desulphurisation of the corresponding 4-thioquinazolines (IV), underwent unusual
