6484-28-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-METHYLQUINAZOLINE-4-THIOL is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Antimicrobial Applications:
2-METHYLQUINAZOLINE-4-THIOL is used as an antimicrobial agent, exhibiting potential activity against a range of microorganisms, which can be beneficial in both medical and agricultural settings.
Used in Antitumor Applications:
2-METHYLQUINAZOLINE-4-THIOL is used as an antitumor agent, showing promise in the study of its potential to combat cancer cells, offering a new avenue for cancer treatment research.
Used in Corrosion Inhibition:
2-METHYLQUINAZOLINE-4-THIOL is used as a corrosion inhibitor for metals, indicating its potential to protect metal surfaces from degradation, which can be valuable in various industrial applications.

InChI:InChI=1/C9H8N2S/c1-6-10-8-5-3-2-4-7(8)9(12)11-6/h2-5H,1H3,(H,10,11,12)/p-1

Upstream product

• 1769-24-0 2-methyl-4-quinazolone 
• 108-24-7 acetic anhydride 
• 1885-29-6 anthranilic acid nitrile 
• 507-09-5 thioacetic acid 
• 25116-00-1 2-acetamidobenzonitrile 
• 118-92-3 anthranilic acid 
• 62-55-5 thioacetamide 
• 6484-24-8 2-methyl-4-chloroquinazoline 
• 507-09-5 tiolacetic acid 
• 89-52-1 o-acetylamino-benzoic acid 
• 2454-39-9 2-aminobenzothioamide 
• 33809-77-7 2-acetamidobenzamide 

Downstream Products

• 771562-35-7 4-(4-chloro-3-methyl-phenyl)-2-(2-methyl-quinazolin-4-ylsulfanyl)-4-oxo-butyric acid 
• 96304-21-1 ω-(2-methyl-4-quinazolinylthio)-acetophenone 
• 1429045-88-4 C₂₃H₁₈N₆S 
• 1429045-87-3 C₂₃H₁₈N₆S 
• 1429045-95-3 C₂₃H₁₇N₃S 
• 37989-48-3 2,5-di-p-tolyl-[1,4]dithiine 
• 4159-03-9 2,5-diphenyl-[1,4]dithiine 
• 37989-51-8 2,5-di(4-methoxyphenyl)-1,4-dithiin 
• 1769-24-0 2-methyl-4-quinazolone 
• 95616-59-4 C₂₇H₁₉N₃O₃S 
• 95616-58-3 C₂₃H₁₉N₃O₃S 
• 95616-48-1 dimethyl 6-methyl-8-oxo-9-phenyl-8H-pyrido<1,2-c>quinazoline-10,11-dicarboxylate 
• 95616-57-2 2-Ethyl-7-methyl-4-phenyl-pyrrolo[3',4':3,4]pyrido[1,2-c]quinazoline-1,3,5-trione 
• 95616-51-6 6-Methyl-8-oxo-9-phenyl-8H-pyrido[1,2-c]quinazoline-11-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

2-Alkyl(aryl)-quinazolin-4(3 H)-thiones, 2-R-(quinazolin-4(3 H)-ylthio)carboxylic acids and amides: Synthesis, molecular docking, antimicrobial and anticancer properties

In this study, a series of novel 2-alkyl(aryl)-quinazolin-4(3H)-thiones, 2-R-(quinazolin-4(3H)-ylthio)carboxylic acids and amides were synthesized and evaluated for antimicrobial and anticancer activities. Their structure was confirmed by elemental analys

Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors

The latest scientific findings concerning PDE7 and PDE4 inhibition suggest that selective small-molecule inhibitors of both enzymes could provide a novel approach to treat a variety of immunological diseases. In this context, we describe a new series of quinazoline derivatives from quinazolin-4-thiones which include a substituted biphenyl fragment. Some of these compounds show inhibitory potencies at sub-micromolar levels against the catalytic domain of PDE7.

Syntheses of Some 4-Anilinoquinazoline Derivatives

Some 4-N-(3′- or 4′-substituted-phenyl)amino-6,7- dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.

Studies on quinazolines. Part I. Annelation to the quinazoline ring utilizing amino acid esters

The reaction of quinazoline-4(3H)-thiones 2a-d with amino acid ester hydrochlorides in boiling solvents, under the basic catalysis, afforded the corresponding substitution products (3-6)a-e in low yield. The reaction could be improved by carrying it without a solvent yielding imidazo[1,2-c]- and pyrimido[1,2-c]quinazolines (7-10)a-e. The antibacterial and antifungal activities of the prepared compounds were tested.

Behaviour of β-(4-chloro-3-methyl)benzoyl Acrylic Acid Towards 2-Methyl-3H-quinazolin-4-thione

β-(4-chloro-3-methyl)benzoylacrylic acid has been reacted with 2-methyl-(3H)-quinazolin-4-thione and gave α-thioquinazoline-β-(4-chloro-3-methyl)benzoyl propionic acid the behaviour of propionic acid derivative towards nitrogen nucleophiles, e.g., hydrazine hydrate, semicarbazide; acid anhydrides, acid amide and benzaldehyde has been discussed.

Phosphodiesterase inhibitory properties of losartan. Design and synthesis of new lead compounds

A 4-centre PDE 4 pharmacophore search has been carried out in several 3D-databases containing compounds belonging to different therapeutic areas. Losartan, an angiotensin-II antagonist, has been identified as a new lead compound for developing PDE 4 inhibitors. New families of compounds derived from losartan has been synthesized and their PDE inhibition has been measured.

SYNTHESIS OF SOME HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD NITROGEN ATOMS

3,5-Dimethyltriazoloquinazoline, 5-methyltetrazoloquinazoline, 5-methyl-s-triazoloquinazoline-3(2H)-thione, 2-quinazolin-3yl)-thiol>-N,N-benzyl-phenylacetanilide, hydrochlorides of 3-substituted phenyl-6-di