6484-28-2

Basic information

• Product Name: 2-METHYLQUINAZOLINE-4-THIOL
• Synonyms: 2-Methyl-3H-quinazoline-4-thione
• CAS NO: 6484-28-2
• Molecular Formula: C₉H₈N₂S
• Molecular Weight: 176.24
• Mol File: 6484-28-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 238.1°C at 760 mmHg
• Flash Point: 97.8°C
• Appearance: /
• Vapor Pressure: 0.0665mmHg at 25°C
• CAS DataBase Reference: 2-METHYLQUINAZOLINE-4-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLQUINAZOLINE-4-THIOL(6484-28-2)
• EPA Substance Registry System: 2-METHYLQUINAZOLINE-4-THIOL(6484-28-2)

Safety Data

• Hazardous Substances Data: 6484-28-2(Hazardous Substances Data)

Usage

General Description

2-Methylquinazoline-4-thiol is a chemical compound with the molecular formula C9H8N2S. It is a sulfur-containing compound that belongs to the quinazoline family. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 2-METHYLQUINAZOLINE-4-THIOL has been studied for its potential biological activities, including its antimicrobial and antitumor properties. Additionally, 2-Methylquinazoline-4-thiol has been investigated for its potential as a corrosion inhibitor for metals. Its unique chemical properties and potential biological activities make it an important compound for further research and development in the field of medicinal and agricultural chemistry.

InChI:InChI=1/C9H8N2S/c1-6-10-8-5-3-2-4-7(8)9(12)11-6/h2-5H,1H3,(H,10,11,12)/p-1

Upstream product

• 108-24-7 acetic anhydride 
• 2454-39-9 2-aminobenzothioamide 
• 1885-29-6 anthranilic acid nitrile 
• 507-09-5 thioacetic acid 
• 1769-24-0 2-methyl-4-quinazolone 
• 89-52-1 o-acetylamino-benzoic acid 
• 118-92-3 anthranilic acid 
• 33809-77-7 2-acetamidobenzamide 
• 507-09-5 tiolacetic acid 
• 6484-24-8 2-methyl-4-chloroquinazoline 
• 62-55-5 thioacetamide 
• 25116-00-1 2-acetamidobenzonitrile 

Downstream Products

• 96304-21-1 ω-(2-methyl-4-quinazolinylthio)-acetophenone 
• 1429045-88-4 C₂₃H₁₈N₆S 
• 1429045-87-3 C₂₃H₁₈N₆S 
• 1429045-95-3 C₂₃H₁₇N₃S 
• 37989-48-3 2,5-di-p-tolyl-[1,4]dithiine 
• 4159-03-9 2,5-diphenyl-[1,4]dithiine 
• 37989-51-8 2,5-di(4-methoxyphenyl)-1,4-dithiin 
• 1769-24-0 2-methyl-4-quinazolone 
• 95616-59-4 C₂₇H₁₉N₃O₃S 
• 95616-58-3 C₂₃H₁₉N₃O₃S 
• 95616-48-1 dimethyl 6-methyl-8-oxo-9-phenyl-8H-pyrido<1,2-c>quinazoline-10,11-dicarboxylate 
• 95616-57-2 2-Ethyl-7-methyl-4-phenyl-pyrrolo[3',4':3,4]pyrido[1,2-c]quinazoline-1,3,5-trione 
• 95616-51-6 6-Methyl-8-oxo-9-phenyl-8H-pyrido[1,2-c]quinazoline-11-carboxylic acid ethyl ester 
• 94392-52-6 anhydro-3-hydroxy-5-methyl-2-phenylthiazolo<3,2-c>quinazolin-4-ium hydroxide 

Relevant articles and documents

2-Alkyl(aryl)-quinazolin-4(3 H)-thiones, 2-R-(quinazolin-4(3 H)-ylthio)carboxylic acids and amides: Synthesis, molecular docking, antimicrobial and anticancer properties

In this study, a series of novel 2-alkyl(aryl)-quinazolin-4(3H)-thiones, 2-R-(quinazolin-4(3H)-ylthio)carboxylic acids and amides were synthesized and evaluated for antimicrobial and anticancer activities. Their structure was confirmed by elemental analys

Syntheses of Some 4-Anilinoquinazoline Derivatives

Some 4-N-(3′- or 4′-substituted-phenyl)amino-6,7- dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.

Studies on quinazolines. Part I. Annelation to the quinazoline ring utilizing amino acid esters

The reaction of quinazoline-4(3H)-thiones 2a-d with amino acid ester hydrochlorides in boiling solvents, under the basic catalysis, afforded the corresponding substitution products (3-6)a-e in low yield. The reaction could be improved by carrying it without a solvent yielding imidazo[1,2-c]- and pyrimido[1,2-c]quinazolines (7-10)a-e. The antibacterial and antifungal activities of the prepared compounds were tested.