85696-67-9Relevant academic research and scientific papers
Synthesis of benzanilide derivatives as dual acting agents with α1- adrenoceptor antagonistic action and steroid 5-α reductase inhibitory activity
Yoshida, Kiyoshi,Horikoshi, Yoichiro,Eta, Masaaki,Chikazawa, Jun,Ogishima, Masayuki,Fukuda, Yohichi,Sato, Hiroki
, p. 2967 - 2972 (2007/10/03)
Synthesis of benzanilide derivatives which have dual α1-adrenoceptor antagonistic action and steroid 5α-reductase inhibitory activity and their structure-activity relationships is described.
EFFETS POLAIRES DANS LES REACTIONS DE TRANSFERT HOMOLYTIQUE INTRAMOLECULAIRE D'HYDROGENE
Lefort, D.,Nedelec, J. Y.
, p. 2681 - 2686 (2007/10/02)
In this paper we analyse the influence of a phenyl substituent on the relative rates of the 1-5 and 1-6 intramolecular hydrogen transfers.Compared to the abstraction of an aliphatic H atom, the activation energy for the abstraction of a benzylic H atom is smaller.The effect is nevertheless more important with a primary alkyl radical (1,3 kcal/mole) than with an alkoxy radical (0,9 kcal/mole).This can be analysed in terms of a polar effect.In addition, the size of the effect is too small to make a short distance transfer of a H atom feasible; this is in keeping with the statement that H atom migration requires a linear transition state.
