857086-94-3

Basic information

• Product Name: (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
• Synonyms: (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;Bedaquiline (1R,2R)Isomer Impurity 2;(αR,βR)-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol
• CAS NO: 857086-94-3
• Molecular Formula: C₃₂H₃₁BrN₂O₂
• Molecular Weight: 541.47816
• EINECS: -0
• Mol File: 857086-94-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Solubility: DCM, Toluene
• CAS DataBase Reference: (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol(857086-94-3)
• EPA Substance Registry System: (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol(857086-94-3)

Safety Data

• Hazardous Substances Data: 857086-94-3(Hazardous Substances Data)

Usage

Description

(1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 1R and 2R positions, a 6-bromo-2-methoxyquinolin-3-yl group, a methylamino group, a naphthalen-1-yl group, and a phenylbutan-2-ol moiety. (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol serves as an important intermediate in the synthesis of various pharmaceuticals and has potential applications in the development of new drugs.

Uses

Used in Pharmaceutical Industry:
(1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol is used as an intermediate in the synthesis of (αS,βR)-Bedaquiline (B119540), a diarylquinoline derivative that acts as a mycobacterial inhibitor. This makes it a crucial component in the development of new drugs for the treatment of tuberculosis and other mycobacterial infections.
As an intermediate in the synthesis of other pharmaceuticals:
Due to its unique structure and functional groups, (1R,2R)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol can be used as a starting material or intermediate in the synthesis of other pharmaceutical compounds with potential therapeutic applications. Its versatility in chemical reactions allows for the development of new drugs with improved efficacy and reduced side effects.

Upstream product

• 73568-35-1 6-bromo-2-chloro-3-formylquinoline 
• 1298044-24-2 (2R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanol 
• 1298044-21-9 C₁₈H₁₄BrNO₂ 
• 1298044-19-5 (2R,3R)-3-(6-bromo-2-methoxyquinolin-3-yl)-3-phenylpropane-1,2-diol 
• 1298044-10-6 [(2S,3S)-3-(6-bromo-2-methoxyquinolin-3-yl)oxiran-2-yl]methanol 
• 1298044-17-3 (E)-3-(6-bromo-2-methoxyquinolin-3-yl)prop-2-en-1-ol 
• 1298044-15-1 (E)-3-(6-bromo-2-chloroquinolin-3-yl)prop-2-en-1-ol 
• 1298044-13-9 ethyl (E)-3-(6-bromo-2-chloroquinolin-3-yl)acrylate 
• 1298044-33-3 (4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-hydroxy-3-(naphthalen-1-yl)-4-phenylbutyl methanesulfonate 
• 124-40-3 dimethyl amine 
• 1298044-31-1 (4R)-4-(6-bromo-2-methoxyquinolin-3-yl)-3-(naphthalen-1-yl)-4-phenylbutane-1,3-diol 
• 1298044-29-7 C₃₀H₂₄BrNO₃ 
• 1298044-27-5 (1R)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(naphthalen-1-yl)-1-phenylpent-4-en-2-ol 
• 1298044-25-3 (2R)-2-(6-bromo-2-methoxyquinolin-3-yl)-1-(naphthalen-1-yl)-2-phenylethanone 

Relevant articles and documents

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