85719-72-8

Upstream product

• 85719-71-7 methylbis(1-methylethoxy)(3-pyridylmethyl)silane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 100-55-0 3-hydroxymethylpyridin 
• 626-55-1 3-Bromopyridine 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 100-55-0 3-hydroxymethylpyridin 
• 65362-92-7 (3,5-di-tert-butyl-4-hydroxyphenyl)methyl-(3-pydidyl)methyl ether 

Relevant academic research and scientific papers

KF/clinoptilolite NPs: An efficient and heterogeneous catalyst for chemoselective silylation of alcohols and phenols

Potassium fluoride incorporated on clinoptilolite nanoparticles (KF/CP NPs) by ion exchanging is found to be an effective and inexpensive heterogeneous nanocatalyst for chemoselective silylation of alcohols and phenols with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) at room temperature. Nano-powder of clinoptilolite (CP) was prepared using a planetary ball mill mechanically method and characterized by dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscope (SEM) analyses. Almost all of products were obtained in high yields as well as short reaction times and the catalyst was also reused eight times without loss of its catalytic activity.

Chlorozincate(II) acidic ionic liquid: Efficient and biodegradable silylation catalyst

A practical and highly efficient silylation of alcohol and phenol derivatives with hexamethyldisilazane (HMDS) using acidic ionic liquids under mild reaction conditions is described. A series of Br?nsted as well as Br?nsted–Lewis acidic ionic liquids were prepared and their performance investigated for the silylation of a wide variety of alcohols and phenols with HMDS. Imidazole- as well as N-methyl-2-pyrrolidone-based acidic ionic liquids have a higher catalytic activity for the protection of sensitive, hindered alcohols and phenols, thus providing an environmentally begin and versatile alternative to current acid catalysts. In addition, the acidic ionic liquids are reusable, being recovered easily and reused several times without significant deterioration in catalytic activity.

Highly efficient and chemoselective trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS) catalyzed by reusable electron-deficient [TiIV(salophen)(OTf)2]

In the present work, highly efficient trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS) catalyzed by high-valent [Ti IV(salophen)(OTf)2] is reported. Under these conditions, primary, secondary and tertiary alcohols as well as phenols were silylated in short reaction times and high yields. It is noteworthy that this method can be used for chemoselective silylation of primary alcohols in the presence of secondary and tertiary alcohols and phenols. The catalyst was reused several times without loss of its catalytic activity.

Pyridylmethylsilanes as dicarboxyacid receptors: Experimental and theoretical study

A series of literature known (1-3) [1-4] and new Si-tripodal receptors for anion sensing, based on 1-3 pyridylmethyl functionalized side arms as recognition sites, was designed, successfully synthesized and characterized by 1H and 13C NMR spectra (4-9). These ligands showed high selectivity and strong binding affinity toward investigated dicarboxyacid anions. The complexes formation was confirmed by 19F NMR spectra. All supramolecular complexes were structurally authenticated using parametric method 5 (PM5) with the MO-G for SCIGRESS program. The results brought information of the type and nature of intermolecular interactions present in the complexes and extended structures.

Polyvinylpolypyrrolidoniume tribromide as new and metal-free catalyst for the formylation and trimethylsilylation of hydroxyl group

Trimethylsilylation of alcohols was achieved using 1,1,1,3,3,3- hexamethyldisilazane (HMDS) as silylating agent, in the presence of polyvinylpolypyrrolidoniume tribromide in acetonitrile at room temperature. Also a variety of alcohols were converted into alkyl formates by ethyl formate and a catalytic amount of polyvinylpolypyrrolidoniume tribromide under solvent free conditions at room temperature.

Rapid and efficient protection of alcohols and phenols, and deprotection of trimethylsilyl ethers catalyzed by a cerium-containing polyoxometalate

Herein, we want to report a simple and convenient way for protection-deprotection of alcohols in the presence of ammonium decatungstocerate(IV) {(NH4)8[CeW10O 36]A·20H2O} as catalyst under ambient temperature in CH3CN. Using 0.002 mmol of the catalyst, various alcohols and phenols were transformed easily to the corresponding TMS ethers in excellent yields. In the second part, various TMS ethers were successfully converted to the parent hydroxyl compounds in the presence of the ammonium decatungstocerate(IV) catalyst.

Efficient trimethylsilylation and tetrahydropyranylation of alcohols in the presence of 1,3-dibromo-5,5-dimethylhydantoin

Chemoselective trimethylsilylation and tetrahydropyranylation of benzylic and primary and secondary aliphatic alcohols proceed efficiently in the presence of 1,3-dibromo-5,5-dimethylhydantoin (DBH) under mild and completely heterogeneous reaction conditio

(Diisopropoxymethylsilyl)methyl Grignard Reagent: A New, Practically Useful Nucleophilic Hydroxymethylating Agent

The (diisopropoxymethylsilyl)methyl Grignard reagent serves as a new, versatile nucleophilic hydroxymethylating agent of organic halides via the metal-catalyzed cross-coupling and the subsequent oxidative cleavage of the silicon-carbon bond