857271-71-7Relevant academic research and scientific papers
One-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles by a tandem three-component reaction of hydroxylamines, aldehydes and 2-azido acrylates
Hu, Bao,Ai, Ning,Wang, Zhao,Xu, Xiaoliang,Li, Xiaonian
experimental part, p. 222 - 228 (2012/06/01)
The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2- azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields. ARKAT-USA, Inc.
Neurokinin-3 receptor modulators: diaryl imidazole derivatives
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Page/Page column 18, (2010/02/12)
The invention relates to compounds of general Formula I: wherein the variables are as defined herein. Also provided are pharmaceutical compositions comprising such compounds, and methods for treating patients suffering from a disorder responsive to neurok
