857463-58-2Relevant academic research and scientific papers
Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling
Jin, Qingwu,Williams, David C.,Hezari, Mehri,Croteau, Rodney,Coates, Robert M.
, p. 4667 - 4675 (2007/10/03)
Taxadiene synthase catalyzes the cyclization of (E,E,E)-geranylgeranyl diphosphate (GGPP) to taxa-4(5),11(12)-diene (Scheme 1, 5 → 2) as the first committed step of Taxol biosynthesis. Deuterated GGPPs labeled stereospecifically at C-1, C-4, and C-16 were
