85758-06-1Relevant articles and documents
Catalytic enantioselective Negishi reactions of racemic secondary benzylic halides
Arp, Forrest O.,Fu, Gregory C.
, p. 10482 - 10483 (2007/10/03)
This report describes the first enantioselective cross-couplings of racemic secondary benzylic halides, specifically, nickel-catalyzed Negishi reactions of bromides and chlorides. The catalyst components are commercially available and air-stable, and the reaction is not highly oxygen- or moisture-sensitive (it can be set up in the air). The method has been applied to the catalytic enantioselective synthesis of intermediates employed by others in the generation of bioactive compounds (e.g., trikentrin A and an androgen receptor agonist). Copyright
Enantiodivergent Route to the Aromatic Bisabolane Sesquiterpenes via a Chiral Acetylene Alcohol
Takano, Seiichi,Sugihara, Takumichi,Samizu, Kiyohiro,Akiyama, Masashi,Ogasawara, Kunio
, p. 1781 - 1784 (2007/10/02)
Efficient preparation and practical utilization of (R)-1-benzyloxy-3-butyn-2-ol have been established.Treatment of (2S,3S)-4-benzyloxy-2,3-epoxybutyl chloride, obtained via the Sharpless epoxidation, with n-butyllithium afforded (R)-1-benzyloxy-3-butyn-2-
THE FIRST STEREOSELECTIVE SYNTHESIS OF (+)-NUCIFEROL AND (+)-NUCIFERAL
Takano, Seiichi,Goto, Emiko,Ogasawara, Kunio
, p. 5567 - 5570 (2007/10/02)
Using (S)-benzyl 2,3-epoxypropyl ether (1), the first stereoselective synthesis of (+)-nuciferol (14) and (+)-nuciferal (16) has been achieved.Employing the same methodology an enantioselective synthesis of (+)-α-curcumene (17) is also described.