25532-74-5

Upstream product

• 7020-81-7 propylidene-t-butylamine 
• 3241-74-5 (S)-4-p-tolylpentanal 
• 43161-07-5 ((2-methylallyl)sulfinyl)benzene 
• 1786-15-8 (S,E)-nuciferol 
• 85764-98-3 1-((S)-4-Benzyloxy-3-phenylsulfanyl-1-phenylsulfanylmethyl-butyl)-4-methyl-benzene 
• 85758-06-1 1-((S)-4-Benzyloxy-1-methyl-butyl)-4-methyl-benzene 
• 807331-98-2 (S,E)-ethyl 2-methyl-6-p-tolylhept-2-enoate 
• 807331-97-1 (4S,2E)-ethyl 4-p-tolylpent-2-enoate 
• 122091-53-6 2-(4-methylphenyl)propanal 
• 19876-64-3 (S)-(+)-4-p-tolylpentan-1-ol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 24720-64-7 2-(triphenylphosphoranylidene)propionaldehyde 
• 78339-53-4 (S,Z)-2-methyl-6-(p-tolyl)hept-2-en-1-ol 
• 145679-15-8 methyl α-(p-methylphenyl)propionate 

Downstream Products

• 1786-15-8 (S,E)-nuciferol 

Relevant academic research and scientific papers

Enantioselective synthesis of (+)-nuciferal, (+)-(E)-nuciferol and (+)-α-curcumene by chiral hydrogenesterification reaction

Using chiral hydrogenesterification reaction as the key step, the stereoselective synthesis of (+)-nuciferal 1, (+)-(E)-nuciferol 2 and (+)-a-curcumene 3 has been achieved.

Baker's yeast mediated enantioselective synthesis of the bisabolane sesquiterpenes curcumene, turmerone, dehydrocurcumene and nuciferal

Fermenting baker's yeast converts the allylic alcohol 6 into enantiomerically pure (S)-(+)-3-(p-tolyl)butan-1-ol 7 which is a useful chiral building block for the synthesis of bisabolane sesquiterpenes. The versatility of this approach is shown in the preparation of (S)-(+)-curcumene, (S)-(+)-turmerone, (S)-(+)-dehydrocurcumene and (E,S)-(+)-nuciferal.

THE FIRST STEREOSELECTIVE SYNTHESIS OF (+)-NUCIFEROL AND (+)-NUCIFERAL

Using (S)-benzyl 2,3-epoxypropyl ether (1), the first stereoselective synthesis of (+)-nuciferol (14) and (+)-nuciferal (16) has been achieved.Employing the same methodology an enantioselective synthesis of (+)-α-curcumene (17) is also described.