85763-14-0

Upstream product

• 57409-49-1 methyl 2,4-dioxo-6-phenylhex-5-enoate 
• 1896-62-4 (E)-benzalacetone 
• 95-92-1 oxalic acid diethyl ester 
• 57409-49-1 methyl (E)-6-phenyl-2,4-dioxohex-5-enoate 
• 122-57-6 1-Phenylbut-1-en-3-one 

Downstream Products

• 1027-41-4 ethyl (E)-2,4-dioxo-6-phenylhex-5-enoate 
• 57409-49-1 methyl (E)-6-phenyl-2,4-dioxohex-5-enoate 

Relevant academic research and scientific papers

Five-membered 2,3-Dioxoheterocycles. XLIV. Synthesis and Nucleophilic Reactions of 5-(β-Styryl)-2,3-dihydro-2.3-furandione

Cyclization of cinnamoylpyruvic acid results in 5-(β-styryl)-2,3-dihydro-2.3-furandione. Its reactions were studied with nucleophilic reagents: water, alcohols, acetone oxime, amines, o-aminophenol, and o-phenylenediamine. Geometric and electronic structure of cinnamoylpyruvic acid, 5-(β-styryl)-2,3-dihydro-2.3-furandione, and mechanism of formation of methyl cinnamoylpyruvate was investigated by quantum-chemical LCAO MO method in AMI approximation.

Inhibitors of Glycolic Acid Oxidase. 4-Substituted 2,4-Dioxobutanoic Acid Derivatives

Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized.These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase.The I50 value of the two most potent representatives, 4-(4'-bromo-4-yl)-2,4-dioxobutanoic acid (8) and 4-thio>-4-yl>-2,4-dioxobutanoic acid (13) is 6 * 10-8 M.