57409-49-1

Upstream product

• 600-23-7 oxalic acid monomethyl ester 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1896-62-4 (E)-benzalacetone 
• 67-56-1 methanol 
• 209455-66-3 5-((E)-Styryl)-furan-2,3-dione 
• 553-90-2 Dimethyl oxalate 
• 1027-41-4 ethyl (E)-2,4-dioxo-6-phenylhex-5-enoate 
• 85763-14-0 (E)-2,4-Dioxo-6-phenyl-hex-5-enoic acid 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 39088-76-1 5-trans-styryl-isoxazole-3-carboxylic acid methyl ester 
• 85763-14-0 2,4-dioxo-6-phenyl-hex-5-enoic acid 
• 78526-66-6 methyl 5,6-dibromo-2,4-dioxo-6-phenylhexanoate 
• 2397-79-7 2-phenyl-4H-pyran-4-one 
• 1083-01-8 4-oxo-6-phenyl-4H-pyrane-2-carboxylic acid 
• 2397-77-5 Ethyl 4-oxo-6-phenyl-4H-pyran-2-carboxylate 
• 78526-45-1 4'-Benzylsulfanyl-2-phenyl-4'H-[1,1']bipyridinyl-4-one 
• 78526-46-2 2-Phenyl-4'-p-tolylsulfanyl-4'H-[1,1']bipyridinyl-4-one 
• 852247-25-7 5-trans-styryl-isoxazole-3-carboxylic acid 
• 85763-14-0 (E)-2,4-Dioxo-6-phenyl-hex-5-enoic acid 
• 1148613-21-1 5-(4-chlorophenyl)-3-hydroxy-4-(3-phenylprop-2-enoyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one 
• 1148613-19-7 3-hydroxy-5-phenyl-4-(3-phenylprop-2-enoyl)-1-(1,3-thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one 

Relevant academic research and scientific papers

Five-membered 2,3-Dioxoheterocycles. XLIV. Synthesis and Nucleophilic Reactions of 5-(β-Styryl)-2,3-dihydro-2.3-furandione

Cyclization of cinnamoylpyruvic acid results in 5-(β-styryl)-2,3-dihydro-2.3-furandione. Its reactions were studied with nucleophilic reagents: water, alcohols, acetone oxime, amines, o-aminophenol, and o-phenylenediamine. Geometric and electronic structure of cinnamoylpyruvic acid, 5-(β-styryl)-2,3-dihydro-2.3-furandione, and mechanism of formation of methyl cinnamoylpyruvate was investigated by quantum-chemical LCAO MO method in AMI approximation.

Inhibitors of Glycolic Acid Oxidase. 4-Substituted 2,4-Dioxobutanoic Acid Derivatives

Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized.These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase.The I50 value of the two most potent representatives, 4-(4'-bromo-4-yl)-2,4-dioxobutanoic acid (8) and 4-thio>-4-yl>-2,4-dioxobutanoic acid (13) is 6 * 10-8 M.

Synthetic Applications of N-N Linked Heterocycles. Part 12. The Preparation of 4-Alkylthio- and 4-Arylthio-pyridines by Regiospecific Attack of Thioalkoxide Ions on N-(4-Oxopyridin-1-yl)pyridinium Salts

Thiolate ions add regiospecifically to N-(4-oxopyridin-1-yl)pyridinium salts (2)-(7) to give in good to excellent yields only the 1,4-dihydropyridine adducts (8)-(13), regardless of whether or not the pyridone moiety carries substituents for sterically shielding the 2- and 6-positions of the pyridinium ring.The addition is believed to be thermodynamically controlled.Decomposition of the dihydro-adducts under free-radical conditions, or by pyrolysis, gives good yields of pyridin-4-yl thioethers (14) and (16) though the reaction failed with the 2-methyl adducts (9).An improved synthesis of 6-methyl-4-oxopyran-2-carboxylic acid is also described.