1027-41-4

Upstream product

• 141-52-6 sodium ethanolate 
• 95-92-1 oxalic acid diethyl ester 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1896-62-4 (E)-benzalacetone 
• 85763-14-0 (E)-2,4-Dioxo-6-phenyl-hex-5-enoic acid 

Downstream Products

• 40753-30-8 5-styryl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester 
• 1083-01-8 4-oxo-6-phenyl-4H-pyrane-2-carboxylic acid 
• 2397-77-5 Ethyl 4-oxo-6-phenyl-4H-pyran-2-carboxylate 
• 102467-68-5 1,5-bis-(4-bromo-phenyl)-3-trans-cinnamoyl-formazan 
• 109866-41-3 1-phenyl-5-trans-styryl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 39088-76-1 5-trans-styryl-isoxazole-3-carboxylic acid methyl ester 
• 39088-85-2 5-[(E)-2-phenylethenyl]-3-isoxazolecarboxylic acid ethyl ester 
• 112080-14-5 C₃₆H₃₀N₆O₄ 
• 85814-93-3 4-hydroxy-6-phenylpyridine-2-carboxamide 
• 78296-37-4 4-hydroxy-6-phenylpyridine-2-carboxylic acid 
• 57050-20-1 4-oxo-6-phenyl-4H-pyran-2-carboxamide 
• 1154-90-1 Ethyl 5,6-dibromo-2,4-dioxo-6-phenylhexanoate 
• 1241726-45-3 3-(1,5-diphenyl-1H-pyrazol-3-yl)-1H-indole-2-carboxylic acid 
• 1241726-44-2 3-(1,5-diphenyl-1H-pyrazol-3-yl)-2-(2-phenylhydrazono)propionic acid 

Relevant academic research and scientific papers

Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines

Parallel synthesis of diverse heterocyclic-tetrahydro-1H-cyclopenta[c]quinolines in excellent yields and high endo diastereoselectivity has been described hereia These compounds are highly functionalized natural product-like tricyclic systems, which may be useful as biologically relevant targets. Fine tuning of the reaction conditions need to be performed depending on the nature and molecular structure of the heterocyclic aromatic carbaldehyde, as well as the choice of the Lewis acid catalyst. Synthesis of the heterocyclic aromatic aldehyde precursors of the Povarov Reaction is also described.

SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS

The present invention belongs to the field of EPl receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EPl receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EPl receptor as well as to pharmaceutical compositions comprising them.

SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.

Five-membered 2,3-Dioxoheterocycles. XLIV. Synthesis and Nucleophilic Reactions of 5-(β-Styryl)-2,3-dihydro-2.3-furandione

Cyclization of cinnamoylpyruvic acid results in 5-(β-styryl)-2,3-dihydro-2.3-furandione. Its reactions were studied with nucleophilic reagents: water, alcohols, acetone oxime, amines, o-aminophenol, and o-phenylenediamine. Geometric and electronic structure of cinnamoylpyruvic acid, 5-(β-styryl)-2,3-dihydro-2.3-furandione, and mechanism of formation of methyl cinnamoylpyruvate was investigated by quantum-chemical LCAO MO method in AMI approximation.