85809-67-2

Upstream product

• 85809-60-5 Acetic acid (R)-(4-chloro-phenyl)-((S)-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-methyl ester 
• 85809-60-5 Acetic acid (S)-(4-chloro-phenyl)-((S)-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-methyl ester 
• 5325-20-2 2H-1,4-benzothiazin-3-one 
• 104-88-1 4-chlorobenzaldehyde 
• 37142-87-3 4-methyl-1,4-benzothiazin-3(4H)-one 
• 83170-65-4 2-(α-hydroxy-p-chlorobenzyl)-4-methyl-3,4-dihydro-3-oxo-2H-benzothiazine 
• 83170-65-4 2-(α-hydroxy-p-chlorobenzyl)-4-methyl-3,4-dihydro-3-oxo-2H-benzothiazine 

Downstream Products

• 87833-84-9 2-[Chloro-(4-chloro-phenyl)-methyl]-2-hydroxy-4-methyl-4H-benzo[1,4]thiazin-3-one 

Relevant academic research and scientific papers

Synergistic promoting effect of ball milling and KF–alumina support as a green tool for solvent-free synthesis of 2-arylidene-benzothiazinones

A solvent-free procedure is developed for the reaction of benzothiazinones with benzaldehyde derivatives, where the solid KF–Al2O3 support and ball milling synergistically leads to a green and efficient synthesis of several 2-arylide

A Simple Ring-expansion of 1,4-Benzothiazines to give 1,5-Benzothiazepines

A new ring-expansion of 2-phenylmethylene-2H-1,4-benzothiazin-3(4H)-ones (1) to give 2,3-dihydro-3-oxo-2-phenyl-1,5-benzothiazepin-4(5H)-ones (3) has been developed; an episulphonium ion intermediate could be involved.

STEREOSELECTIVE SYNTHESIS OF 2-ALKYLIDENE-3,4-DIHYDRO-3-OXO-2H-1,4-BENZOTHIAZINES

Metallation of 4-methyl-3,4-dihydro-3-oxo-2H-1,4-benzothiazine with LDA and subsequent reaction with aldehydes leads to diastereomeric aldols 4 and 5.Acetylation followed by acetic acid elimination of the aldols provides a stereoselective and high yield route to 2-alkylidene-3,4-dihydro-3-oxo-2H-1,4-benzothiazines.