37142-87-3

Upstream product

• 79-08-3 bromoacetic acid 
• 21749-63-3 2-(methylamino)benzenethiol 
• 79-11-8 chloroacetic acid 
• 5325-20-2 2H-1,4-benzothiazin-3-one 
• 74-88-4 methyl iodide 
• 70413-84-2 4-methyl-4H-benzo[1,4]thiazin-3-ylideneamine; hydrochloride 
• 39639-85-5 4-methyl-4H-benzo[1,4]thiazine-3-thione 
• 105-36-2 ethyl bromoacetate 
• 67-64-1 acetone 
• 1239573-75-1 2-chloro-N-(2-iodophenyl)-N-methylacetamide 
• 909405-84-1 C₉H₁₀INOS 
• 1420043-15-7 C₁₁H₁₂INO₂S 
• 615-43-0 2-iodophenylamine 
• 1339628-12-4 N-(2-iodophenyl)-2-bromoacetamide 

Downstream Products

• 70685-19-7 2-(2-methoxy-benzoyl)-4-methyl-4H-benzo[1,4]thiazin-3-one 
• 70685-20-0 2-(2-amino-benzoyl)-4-methyl-4H-benzo[1,4]thiazin-3-one 
• 83170-55-2 2-benzyl-4-methyl-2H-benzo[b][1,4]thiazin-3(4H)-one 

Relevant academic research and scientific papers

An efficient ligand-free ferric chloride catalyzed synthesis of annulated 1,4-thiazine-3-one derivatives

A straight forward route for the synthesis of coumarin-, quinolone-annulated 1,4-thiazine-3-one derivatives has been achieved by using sodium sulfide as the sulfur source and ferric chloride as catalyst in a ligand-free condition. The synthetic procedure is simple, inexpensive, and affords the products in good yields. This methodology is also applicable to naphthalene and benzene systems.

An efficient ligand-free ferric chloride catalyzed synthesis of annulated 1,4-thiazine-3-one derivatives

A straight forward route for the synthesis of coumarin-, quinolone-annulated 1,4-thiazine-3-one derivatives has been achieved by using sodium sulfide as the sulfur source and ferric chloride as catalyst in a ligand-free condition. The synthetic procedure is simple, inexpensive, and affords the products in good yields. This methodology is also applicable to naphthalene and benzene systems.

Nickel-mediated inter- and intramolecular C-S coupling of thiols and thioacetates with aryl iodides at room temperature

A Ni(0)-catalyzed intermolecular cross-coupling of various functionalized thiols and aryl iodides has been developed and successfully extended to less explored intramolecular versions, where thioacetates could also be utilized as the strategic surrogate. Air-stable precatalysts, very mild conditions, and an easy protocol allow rapid access to medicinally useful aryl thioethers, as demonstrated in the facile synthesis of (±)-chuangxinmycin as a key step.

AZO METAL CHELATE DYE AND OPTICAL RECORDING MEDIUM

To provide a dye to be used for an optical recording medium excellent in both high speed recording characteristics and reproduction durability. A dye having an azo compound represented by the following formula coordinated to a metal ion: wherein the ring

Copper-catalyzed cascade syntheses of 2 H -benzo[ b ][1,4]thiazin-3(4 H)-ones and quinoxalin-2(1 H)-ones through capturing S and N atom respectively from AcSH and TsNH2

A copper-catalyzed cascade method has been developed to synthesize the 2H-benzo[b][1,4]thiazin-3(4H)-ones from 2-halo-N-(2-halophenyl)-acetamides 1 and AcSH via the SN2/deacetylation/coupling process, and to synthesize the quinoxalin-2(1H)-ones from 1 and TsNH2 via the S N2/coupling/desulfonation process. The target products were obtained with diversity at three positions on their scaffolds.

Synthesis and antiinflammatory activity of some newer N-(substituted phenyl)-2HI4H-benzo [b] [1,4] thiazin-3-amines

2-Aminothiophenol on condensation with ethyl chloroacetate gave 2H-benzo [b] [1,4] thiazin-3[4H]-one 1 which on chlorination with POCl3 yielded 3- chloro-2H-benzo [b] [1,4]-thiazine 2, compound 2 with substituted anilines yielded N-(substituted phenyl)-2H-benzo [b] [1,4] thiazine-3-amines 3a-f. 2 on the other hand on methylation with methyl iodide gave 4-methyl-2H-benzo [b] [1,4] thiazin-3(4H)-one 4, which on chlorination with POCl3 yielded 3-chloro-4-methyl-4H-benzo [b] [1,4] thiazine 5,5 on treatment with substituted anilines gave 4-methyl-N-(substituted phenyl)-2H-benzo [b] [1,4]-thiazin-3-amines 6a-f. The structures of newly synthesized compounds were elucidated on the basis of FTIR, 1H NMR, mass and elemental analysis and screened for their antiinflammatory activity.

An alternative efficient method for transformation of thiocarbonyl to carbonyl group using trifluoroacetic anhydride

A simple and efficient procedure for the rapid and mild conversion of thiocarbonyls to carbonyls in high yields is described.

Synthesis, antibacterial and antifungal activities of several new benzo- naphtho- and quinolino-1,4-thiazine and 1,5-thiazepine derivatives

The synthesis of a number of thiosemicarbazone, phenylthiosemicarbazone, oxime and oxime O-ester derivatives of benzo- naphtho- and quinolino-1,4-thiazines and 1,5-thiazepines is described.All the compounds were tested in vitro for their antimicrobial act

An Improved Alkylation of 2H-1,4-Benzothiazin-3(4H)-one and Related Heterocyclic Anilides

Various N-substituted derivatives of 2H-1,4-benzothiazin-3(4H)-one are obtained in high yields employing functionalized alkyl halides and potassium tert-butoxide in dimethylformamide.The method is mild, regioselective and tolerates a variety of functional groups.