85814-95-5

Upstream product

• 994-89-8 tributylethynyltin 
• 36401-31-7 5-phenyl-1,2,4-triazine-3-carboxylic acid methyl ester 
• 2397-77-5 Ethyl 4-oxo-6-phenyl-4H-pyran-2-carboxylate 
• 85814-93-3 4-hydroxy-6-phenylpyridine-2-carboxamide 

Downstream Products

• 78296-45-4 4-Methoxy-6-phenyl-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide 
• 78296-74-9 N-(5-tetrazolyl)-4-chloro-6-phenylpyridine-2-carboxamide 
• 78296-84-1 N-(5-tetrazolyl)-6-phenylpyridine-2-carboxamide 
• 85814-98-8 4-methoxy-6-phenylpyridine-2-carboxylic acid 
• 85814-96-6 4-chloro-6-phenylpyridine-2-carboxylic acid 
• 85814-97-7 methyl 4-methoxy-6-phenylpyridine-2-carboxylate 

Relevant academic research and scientific papers

Ethynyltributyltin - A synthetic equivalent for acetylene, aryl, acyl and halogeno alkynes in [4+2] cycloadditions

Ethynyltributyltin 2 cycloadds to 5-phenyl-1,2,4-triazine-3-carboxyclic acid methyl eater I to furnish mainly 4-tributylstannyl-6-phenyl-pyridine-2- carboxyclic acid methyl ester 3a besides a small amount of the 3- tributylstannyl isomer 3b. The tributyltin substituent of pyridine 3a can be replaced by Pd-catalyzed acylation and arylation, by halogenation and protonation to yield functionalized pyridines 4 - 7, which are not available by direct cycloaddition of the corresponding alkynes.