2397-77-5

Upstream product

• 1154-90-1 Ethyl 5,6-dibromo-2,4-dioxo-6-phenylhexanoate 
• 64-17-5 ethanol 
• 78526-66-6 methyl 5,6-dibromo-2,4-dioxo-6-phenylhexanoate 
• 57409-49-1 methyl 2,4-dioxo-6-phenylhex-5-enoate 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1027-41-4 2,4-dioxo-6-phenyl-hex-5-enoic acid ethyl ester 
• 1027-41-4 ethyl (E)-2,4-dioxo-6-phenylhex-5-enoate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 76782-46-2 ethyl 6-phenyl-2,4,6-trioxohexanoate 

Downstream Products

• 1083-01-8 4-oxo-6-phenyl-4H-pyrane-2-carboxylic acid 
• 100622-00-2 6-phenyl-4-thioxo-4H-pyran-2-carboxylic acid ethyl ester 
• 57050-17-6 6-phenyl-4-(2,4,6-trioxo-tetrahydro-pyrimidin-5-ylidene)-4H-pyran-2-carboxylic acid ethyl ester 
• 57106-11-3 4-(1,3-dimethyl-2,4,6-trioxo-tetrahydro-pyrimidin-5-ylidene)-6-phenyl-4H-pyran-2-carboxylic acid ethyl ester 
• 57050-20-1 4-oxo-6-phenyl-4H-pyran-2-carboxamide 
• 78296-37-4 4-hydroxy-6-phenylpyridine-2-carboxylic acid 
• 85814-93-3 4-hydroxy-6-phenylpyridine-2-carboxamide 
• 2398-05-2 4-Oxo-6-phenyl-4H-pyran-2-carbaldehyde 
• 85814-94-4 2-cyano-4-hydroxy-6-phenylpyridine 
• 76782-13-3 2-cyano-6-phenyl-4-pyrone 
• 85814-96-6 4-chloro-6-phenylpyridine-2-carboxylic acid 
• 85814-98-8 4-methoxy-6-phenylpyridine-2-carboxylic acid 
• 85814-95-5 methyl 4-chloro-6-phenylpyridine-2-carboxylate 
• 85814-97-7 methyl 4-methoxy-6-phenylpyridine-2-carboxylate 

Relevant academic research and scientific papers

Cytotoxic activity assessment, QSAR and docking study of novel bis-carboxamide derivatives of 4-pyrones synthesized by Ugi four-component reaction

Fourteen novel bis-carboxamide derivatives of 4-pyrones were designed and synthesized via Ugi four-component reactions of 4-pyrone carbaldehydes, aromatic amines, isocyanides and carboxylic acids. The cytotoxic activity of synthesized derivatives was eval

New derivatives of 6-phenylcomanic acid

Ethyl 6-phenylcomanic acid with hydrazine hydrate and hydroxylamine gives 4-oxo-6-phenyl-4H/-pyran-2-carbohydrazide and 4-oxo-6-phenyl-4H-pyran-2- carbohydroxamic acid, whereas 6-phenylcomanic acid with ammonia in aqueous DMSO gives 4-hydroxy-6-phenylpico

Synthesis and reactions of reduced flavones

The cycloadditions of a series of 4H-pyran-4-ones 3c-e with electron-rich dienes 11a,b to give reduced flavones 12 is described. The subsequent reactions of these reduced flavones with HCl, trifluoroacetic anhydride, ethyl anthranilate 19a and anthranilon

Synthetic Applications of N-N Linked Heterocycles. Part 12. The Preparation of 4-Alkylthio- and 4-Arylthio-pyridines by Regiospecific Attack of Thioalkoxide Ions on N-(4-Oxopyridin-1-yl)pyridinium Salts

Thiolate ions add regiospecifically to N-(4-oxopyridin-1-yl)pyridinium salts (2)-(7) to give in good to excellent yields only the 1,4-dihydropyridine adducts (8)-(13), regardless of whether or not the pyridone moiety carries substituents for sterically shielding the 2- and 6-positions of the pyridinium ring.The addition is believed to be thermodynamically controlled.Decomposition of the dihydro-adducts under free-radical conditions, or by pyrolysis, gives good yields of pyridin-4-yl thioethers (14) and (16) though the reaction failed with the 2-methyl adducts (9).An improved synthesis of 6-methyl-4-oxopyran-2-carboxylic acid is also described.