85815-02-7

Upstream product

• 888721-10-6 methyl 2-oxo-2H-[1,2'-bipyridine]-3-carboxylate 
• 43083-13-2 3-cyano-2-hydroxy-6-phenylpyridine 
• 339109-23-8 1-Methyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carbonitrile 
• 56162-63-1 2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid 
• 74-88-4 methyl iodide 
• 125031-47-2 Methyl 1,2-Dihydro-2-oxo-6-phenyl-3-pyridinecarboxylate 
• 85965-88-4 1-Methyl-2-oxo-6-phenyl-1,2-dihydro-pyridine-3-carboxylic acid methyl ester 

Downstream Products

• 85815-20-9 N-(5-tetrazolyl)-1-methyl-6-phenyl-2-pyridone-3-carboxamide 

Relevant academic research and scientific papers

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.