858271-67-7

Basic information

• Product Name: ethyl 2-(4-chlorophenyl)-1H-pyrrole-3-carboxylate
• Synonyms: ethyl 2-(4-chlorophenyl)-1H-pyrrole-3-carboxylate
• CAS NO: 858271-67-7
• Molecular Weight: 249.697
• Mol File: 858271-67-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-chlorophenyl)-1H-pyrrole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-chlorophenyl)-1H-pyrrole-3-carboxylate(858271-67-7)
• EPA Substance Registry System: ethyl 2-(4-chlorophenyl)-1H-pyrrole-3-carboxylate(858271-67-7)

Safety Data

• Hazardous Substances Data: 858271-67-7(Hazardous Substances Data)

Upstream product

• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 

Downstream Products

• 858275-78-2 2-(4-chloro-phenyl)-2,5-dihydro-pyrrole 
• 19867-89-1 2-(4-chlorophenyl)-1H-pyrrole 

Relevant articles and documents

One-Pot Synthesis of 3-Substituted 2-Arylpyrrole in Aqueous Media via Addition-Annulation of Arylboronic Acid and Substituted Aliphatic Nitriles

Pd(II)-catalyzed C-C coupling reactions between substituted aliphatic nitriles and arylboronic acids followed by in situ cyclodehydration have been employed for the first time to synthesize a wide variety of 3-substituted 2-aryl-1H-pyrroles in aqueous acetic acid. This one-pot synthesis is green, and it conforms to atom economy. The structures of two representative pyrroles, 3k and 5f, were confirmed by X-ray crystallographic analysis.