85829-29-4

Basic information

• Product Name: Benzenepropanoyl chloride, 2-Methyl-
• Synonyms: Benzenepropanoyl chloride, 2-Methyl-;3-(2-Methylphenyl)propionoyl chloride
• CAS NO: 85829-29-4
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Mol File: 85829-29-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanoyl chloride, 2-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, 2-Methyl-(85829-29-4)
• EPA Substance Registry System: Benzenepropanoyl chloride, 2-Methyl-(85829-29-4)

Safety Data

• Hazardous Substances Data: 85829-29-4(Hazardous Substances Data)

Upstream product

• 22084-89-5 3-(2-methylphenyl)propanoic acid 
• 79-37-8 oxalyl dichloride 
• 78606-96-9 <(2-methylphenyl)methyl>propanedioic acid 
• 95-49-8 2-methylchlorobenzene 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 6619-57-4 diethyl 2-(2-methylbenzyl)-malonate 

Downstream Products

• 24644-78-8 4-methylindanone 
• 103028-79-1 3-o-tolyl-propionic acid amide 
• 103857-85-8 3-o-tolyl-propionic acid methylamide 
• 90266-00-5 1-Diazo-4-(2-methylphenyl)butan-2-one 
• 4242-15-3 5-methyl-2-tetralone 
• 365554-24-1 2-amino-5-methyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 192987-46-5 4-[1-(1-hydroxy-4-methylindanyl)]-N-(triphenylmethyl)imidazole 
• 31701-18-5 8-Methyl-2-tetralone 
• 133131-48-3 4-methyl-indan-1-one-(2,4-dinitro-phenylhydrazone) 
• 326816-46-0 N-[(3-Chloro-5-trifluoromethyl-2-pyridyl)methyl]-3-(2-tolyl)propionamide 
• 1267874-67-8 1,1,1-trifluoro-4-(o-tolyl)butan-2-one 
• 1400792-53-1 N-methoxy-N-methyl-3-(o-tolyl)propanamide 

Relevant articles and documents

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.

Rh(III)-Catalyzed meta-C-H Olefination Directed by a Nitrile Template

A range of Rh(III)-catalyzed ortho-C-H functionalizations have been developed; however, extension of this reactivity to remote C-H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first examp