22084-89-5

Basic information

• Product Name: 3-(2-METHYLPHENYL)PROPIONIC ACID
• Synonyms: 3-(2-Methylphenyl)propanoic acid;3-(2-METHYLPHENYL)PROPIONIC ACID;2-METHYLHYDROCINNAMIC ACID;3-o-Tolylpropanoic acid;3-(2-Methylphenyl)propionic acid ,99%;2-Methylhydrociamic acid;Benzenepropanoic acid, 2-Methyl-;2-Methyl-benzenepropanoic acid
• CAS NO: 22084-89-5
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Product Categories: C10;Carbonyl Compounds;Carboxylic Acids
• Mol File: 22084-89-5.mol
• Article Data: 23

Chemical Properties

• Melting Point: 100-103 °C(lit.)
• Boiling Point: 293.3 °C at 760 mmHg
• Flash Point: 190.5 °C
• Appearance: /
• Density: 1.097g/cm³
• Vapor Pressure: 0.000792mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:4.66 (25°C)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 3-(2-METHYLPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHYLPHENYL)PROPIONIC ACID(22084-89-5)
• EPA Substance Registry System: 3-(2-METHYLPHENYL)PROPIONIC ACID(22084-89-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 22084-89-5(Hazardous Substances Data)

Usage

Uses

3-(2-Methylphenyl)propionic acid is a carboxylic acid building block. It participates in the synthesis of 2-methyl-3-phenylpropanol.

General Description

2-Methylhydrocinnamic acid is a carboxylic acid building block. It participates in the synthesis of 2-methyl-3-phenylpropanol.

InChI:InChI=1/C10H12O2/c1-8-4-2-3-5-9(8)6-7-10(11)12/h2-5H,6-7H2,1H3,(H,11,12)

Upstream product

• 2373-76-4 2-methylcinnamic acid 
• 103-83-3 N,N'-dimethylbenzylamine 
• 2495-35-4 benzylacrylate 
• 929557-06-2 benzyl 3-(o-tolyl)propanoate 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 89-92-9 2-methylbenzyl bromide 
• 95-49-8 2-methylchlorobenzene 
• 64-18-6 formic acid 
• 611-15-4 1-methyl-2-vinyl-benzene 
• 3495-36-1 cesium formate 
• 124-38-9 carbon dioxide 
• 16793-90-1 1-(2-bromoethyl)-2-methylbenzene 
• 201230-82-2 carbon monoxide 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 

Downstream Products

• 24644-78-8 4-methylindanone 
• 104750-61-0 ethyl 3-(o-tolyl)propanoate 
• 85829-29-4 3-(2-methylphenyl)propionic acid chloride 
• 14902-36-4 3-(2-methylphenyl)-1-propanol 
• 42817-56-1 dimethyl-(3-o-tolyl-propyl)-amine 
• 26465-81-6 3,3-dimethylindan-1-one 
• 37741-54-1 β-(2-tolyl)propionic acid methyl ester 
• 192987-46-5 4-[1-(1-hydroxy-4-methylindanyl)]-N-(triphenylmethyl)imidazole 
• 1620102-47-7 tert-butyl (S)-3-(2-methylbenzyl)-2-oxo-3,4-dihydroquinoline-1(2H)-carboxylate 
• 20151-46-6 5-methyl-1,2,3,4-tetrahydroquinolin-2-one 

Relevant articles and documents

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Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations

Impactful regioselectivity control is crucial for cost-effective chemical synthesis. By using cheap and abundant iron(iii) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99:1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(iii) salts. In addition, similar results were obtained for the carbonylation of secondary alcohols.