85862-71-1

Basic information

• Product Name: 4-(1H-1,2,3-Triazol-1Yl)-Benzonitrile
• Synonyms: 4-(1H-1,2,3-Triazol-1Yl)-Benzonitrile;4-(1H-1,2,3-Triazol-1Yl)-Benzonitrile(WX683316)
• CAS NO: 85862-71-1
• Molecular Formula: C₉H₆N₄
• Molecular Weight: 170.17074
• Mol File: 85862-71-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1H-1,2,3-Triazol-1Yl)-Benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-1,2,3-Triazol-1Yl)-Benzonitrile(85862-71-1)
• EPA Substance Registry System: 4-(1H-1,2,3-Triazol-1Yl)-Benzonitrile(85862-71-1)

Safety Data

• Hazardous Substances Data: 85862-71-1(Hazardous Substances Data)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 288-36-8 1,2,3-triazole 
• 619-72-7 4-nitrobenzonitrile 
• 1194-02-1 4-fluorobenzonitrile 
• 18523-41-6 4-azidobenzonitrile 
• 1066-54-2 trimethylsilylacetylene 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 1616598-39-0 (4-(1H-1,2,3-triazol-1-yl)phenyl)methanamine 
• 1616598-41-4 N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-chloro-5-methylpyrimidin-4-amine 
• 1616598-33-4 N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid 
• 1364524-44-6 4-(1H-4,2,3-triazolyl-1-yl)benzoyl chloride 

Relevant articles and documents

[4 + 1] Annulation of in situ generated azoalkenes with amines: A powerful approach to access 1-substituted 1,2,3-triazoles

1-Substituted 1,2,3-triazoles represents ‘privileged’ structural scaffolds of many clinical pharmaceuticals. However, the traditional methods for their preparation mainly rely on thermal [3 + 2] cycloaddition of potentially dangerous acetylene and azides. Here we report a base-mediated [4 + 1] annulation of azoalkenes generated in situ from readily available difluoroacetaldehyde N-tosylhydrazones (DFHZ-Ts) with amines under relatively mild conditions. This azide- and acetylene-free strategy provides facile access to diverse 1-substituted 1,2,3-triazole derivatives in high yield in a regiospecific manner. This transformation has great functional group tolerance and can suit a broad substrate scope. Furthermore, the application of this novel methodology in the gram-scale synthesis of an antibiotic drug PH-027 and in the late-stage derivatization of several bioactive small molecules and clinical drugs demonstrated its generality, practicability and applicability.

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

INHIBITORS OF THE USP1/UAF1 DEUBIQUITINASE COMPLEX AND USES THEREOF

Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damag