85864-29-5

Usage

Uses

Used in Food Industry:
2-Furancarboxylic acid, tetrahydro-2-methoxy-, methylester (9CI) is used as a flavoring agent for enhancing the taste and aroma of various food products.
Used in Pharmaceutical Industry:
2-Furancarboxylic acid, tetrahydro-2-methoxy-, methylester (9CI) is used as a starting material for the synthesis of other organic compounds with potential pharmacological properties, such as anti-inflammatory and anticancer activities.
Used in Chemical Synthesis:
2-Furancarboxylic acid, tetrahydro-2-methoxy-, methylester (9CI) is used as a starting material for the synthesis of other organic compounds, which can be further utilized in various chemical and pharmaceutical applications.

Upstream product

• 108734-03-8 4,5-dihydro-furan-2-carbonitrile 
• 67-56-1 methanol 
• 3393-45-1 5,6-dihydro-pyran-2-one 

Downstream Products

• 910620-62-1 1-(2-(2-methoxy)tetrahydrofuranyl)-2-phenyl-2-(2-pivaloylamidophenyl)ethanone 
• 85852-03-5 6-hydroxy-1-phenyl-1-(2-pivaloylamidophenyl)-2,3-hexanedione 
• 85852-18-2 1-(2-(2-hydroxy)tetrahydrofuranyl)-2-phenyl-2-(2-pivaloylamidophenyl)ethanone 
• 85852-20-6 tetrahydro-2-hydroxy-2-(phenyl(2-pivaloylamidophenyl)methyl)-3-oxopyran 
• 85852-06-8 1-hydroxy-6-phenyl-6-(2-pivaloylamidophenyl)non-8-ene-4,5-dione 
• 85852-04-6 2-allyloxy-6-hydroxy-1-phenyl-1-(2-pivaloylamidophenyl)hex-1-en-3-one 

Relevant academic research and scientific papers

Synthetic approaches to haplophytine. 1. Synthesis of 1-methoxy- and 1-hydroxy-6-phenyl-6-(2-pivaloylamidophenyl)non-8-ene-4,5-dione and 1-methyl-3-phenyl-3-(pivaloylamidophenyl)-2-pyrrolidinone

An analysis of the structures of the alkaloid haplophytine and its dihydrobromide which is formed with rearrangement, shows that they are both derived from a 7-(2-amino-3-hydroxyphenyl)-7-aryl-9-(methylamino)-5,6-dioxonoanoic acid moiety (3).Approaches to the synthesis of compounds related to 3 are described.The dianion 13 of phenyl(2-pivaloylamidophenyl)methane, that of methyl 2-phenyl-2-(2-pivaloylamidophenyl)acetate, and the trianion 37 of 2-phenyl-2-(2-pivaloylamidophenyl)acetic acid undergo C-alkylation and C-acylation with nucleophiles.Acylation of 13 with methyl 2,2,5-trimethoxypentanoate followed by hydrolysis gives 6-methoxy-1-phenyl-1-(2-pivaloylamidophenyl)-2,3-hexanedione.This with allyl bromide and sodium carbonate gives O-allyl derivative, which on thermolysis is converted to its C-allyl isomer, 1-methoxy-6-phenyl-6-(2-pivaloylamidophenyl)non-8-ene-4,5-dione.The corresponding 1-hydroxy compound was prepared analogously via acylation of 13 with methyl tetrahydro-2-methoxyfuran-2-carboxylate.C-allylation of trianion 37 gives 2-phenyl-2-(2-pivaloylamidophenyl)pent-4-enoic acid, whose methyl ester on ozonolysis followed by treatment with methylamine hydrochloride and sodium cyanoborohydride gives 1-methyl-3-phenyl-3-(2-pivaloylamidophenyl)-2-pyrrolidinone, a potential advanced intermediate for the synthesis of compounds related to 3.