858659-52-6

Basic information

• Product Name: 3-Bromo-5-[(E)-3-phenyl-prop-2-en-(Z)-ylidene]-5H-furan-2-one
• Synonyms: 3-Bromo-5-[(E)-3-phenyl-prop-2-en-(Z)-ylidene]-5H-furan-2-one
• CAS NO: 858659-52-6
• Molecular Weight: 277.117
• Mol File: 858659-52-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Bromo-5-[(E)-3-phenyl-prop-2-en-(Z)-ylidene]-5H-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-[(E)-3-phenyl-prop-2-en-(Z)-ylidene]-5H-furan-2-one(858659-52-6)
• EPA Substance Registry System: 3-Bromo-5-[(E)-3-phenyl-prop-2-en-(Z)-ylidene]-5H-furan-2-one(858659-52-6)

Safety Data

• Hazardous Substances Data: 858659-52-6(Hazardous Substances Data)

Upstream product

• 160252-41-5 3,5-dibromo-5-(bromomethyl)-2(5H)-furanone 
• 76311-90-5 5-methyl-3-bromo-2(5H)-furanone 
• 123-76-2 levulinic acid 
• 591-12-8 5-methyl-2-furanone 
• 591-11-7 5-methyl-5H-furan-2-one 
• 108-28-1 protoanemonin 
• 858659-51-5 (Z)-3-bromo-5-(bromomethylene)-2(5H)-furanone 
• 66680-87-3 (E)-1-phenyl-(2-tributylstannyl)ethene 

Relevant articles and documents

Stepwise cross-couplings of a dibromo-γ-methylenebutenolide as an access to Z-configured α-alkenyl-γ-alkylidenebutenolides. Straightforward synthesis of the antibiotic lissoclinolide

The Z-isomer of α-bromo-γ-(bromomethylene)butenolide was prepared from α-angelica lactone or levulinic acid in three and four steps, respectively. Successive Stille-couplings with an unsaturated stannane, with the potential to use a different second unsaturated stannane, involved the a?-substituent first and the a?-substituent thereafter. Thereby, α-alkenyl-γ-alkylidenebutenolides and their arene analogs were obtained Z-selectively.