85891-12-9

Upstream product

• 66303-55-7 2-(phenylthio)acetaldehyde 
• 108-59-8 malonic acid dimethyl ester 
• 85891-11-8 4-Phenylsulfanyl-4,5-dihydro-pyrazole-3,3-dicarboxylic acid dimethyl ester 
• 108-98-5 thiophenol 

Downstream Products

• 193286-90-7 4-Benzenesulfinylmethyl-2-(2,6-dichloro-pyridin-4-yl)-5-ethyl-6-oxo-1-prop-2-ynyl-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester 
• 193286-89-4 2-(2,6-Dichloro-pyridin-4-yl)-5-ethyl-6-oxo-4-phenylsulfanylmethyl-1-prop-2-ynyl-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester 
• 193286-88-3 2-(2,6-Dichloro-pyridin-4-yl)-5-ethyl-6-oxo-4-phenylsulfanylmethyl-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester 
• 193286-87-2 2-(2,6-Dichloro-pyridin-4-yl)-6-oxo-4-phenylsulfanylmethyl-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of 2-(2,6-dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl- 4(3H)-pyrimidinone, a promising new herbicide

A novel synthesis of the promising new herbicide 2-(2,6-dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl-4- (12) is reported which features (I) regioselective carbon, followed by nitrogen, dialkylation of an intermediate dianion, and 2 a tandem 'one-pot' sequence of reactions involving sigmatropic sulfoxide elimination, lithium chloride-induced demethylation of a carbomethoxy grouping, decarboxylation, and isomerization/aromatization.

The Participation and Migration of a Sulphur Atom Substituent in the Decomposition of Pyrazolines

When appropriate vinyl sulphides, which are activated by two electron-withdrawing groups at the 2-position, react with diazoalkanes they give 4-arylthio-substituted pyrazolines; these undergo accelerated thermal decomposition in which the arylthio-group migrates to the 5-position, with loss of nitrogen, to furnish exclusively the substituted allyl sulphides.