859485-91-9

Usage

Uses

Used in Medicinal Chemistry and Pharmaceutical Research:
(2-phenylthiazol-5-yl)Methanol is used as a building block in the synthesis of new drug candidates for its structural features and potential biological activities. It may contribute to the development of new pharmacologically active compounds.
Used in Material Science and Organic Synthesis:
(2-phenylthiazol-5-yl)Methanol is also used in the field of material science and organic synthesis, where its interesting properties can contribute to various scientific and industrial applications.

Upstream product

• 172678-67-0 ethyl 2-phenyl-1,3-thiazole-5-carboxylate 
• 98-80-6 phenylboronic acid 
• 1011-40-1 2-phenyl-1,3-thiazole-5-carbaldehyde 

Downstream Products

• 859471-93-5 5-(bromomethyl)-2-phenylthiazole 
• 1826-11-5 2-phenylthiazole 
• 110704-38-6 5-(chloromethyl)-2-phenylthiazole 
• 1011-40-1 2-phenyl-1,3-thiazole-5-carbaldehyde 

Relevant academic research and scientific papers

THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

Provided herein are compounds of Formula (I) and Formula (II) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.