85966-69-4

Basic information

• Product Name: phenyl hexylcarbamate
• Synonyms: Carbamic acid, hexyl-, phenyl ester
• CAS NO: 85966-69-4
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.2955
• Mol File: 85966-69-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 304.8°C at 760 mmHg
• Flash Point: 138.1°C
• Density: 1.013g/cm³
• Vapor Pressure: 0.000854mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: phenyl hexylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl hexylcarbamate(85966-69-4)
• EPA Substance Registry System: phenyl hexylcarbamate(85966-69-4)

Safety Data

• Hazardous Substances Data: 85966-69-4(Hazardous Substances Data)

Upstream product

• 111-26-2 hexan-1-amine 
• 1885-14-9 phenyl chloroformate 
• 2525-62-4 Hexyl isocyanate 
• 108-95-2 phenol 
• 102-09-0 bis(phenyl) carbonate 

Downstream Products

• 79353-76-7 N₄-hexylsemicarbazide 
• 92493-70-4 N-(hexylcarbamoyl)-4-methylbenzenesulfonamide 
• 111897-27-9 5-benzyl-3-hexylimidazolidine-2,4-dione 

Relevant articles and documents

Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

We report a new electrochemical supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. This simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure is applicable to different amines, alcohols, and thiols. Furthermore, when single-pass continuous electrochemical flow conditions were used and this reaction was run in a carbon graphite Cgr/Cgr flow cell, urea compounds could be obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable.

Preparation of substituted semicarbazides from corresponding amines and hydrazines via phenyl carbamates

A simple synthetic procedure for the conversion of amines and hydrazines into substituted semicarbazides was developed. The initial condensation between the desired amine and phenyl chloroformate into phenyl carbamate is followed by the addition of hydrazine under basic conditions. The reaction is tolerable to a variety of functional groups, with mild conditions and high percent yields.

Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives

Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox.