860-55-9

Basic information

• Product Name: N-[(benzyloxy)carbonyl]phenylalanylserine
• CAS NO: 860-55-9
• Molecular Formula: C₂₀H₂₂N₂O₆
• Molecular Weight: 386.3985
• Mol File: 860-55-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 717.6°C at 760 mmHg
• Flash Point: 387.8°C
• Density: 1.318g/cm³
• Vapor Pressure: 1.3E-21mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: N-[(benzyloxy)carbonyl]phenylalanylserine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(benzyloxy)carbonyl]phenylalanylserine(860-55-9)
• EPA Substance Registry System: N-[(benzyloxy)carbonyl]phenylalanylserine(860-55-9)

Safety Data

• Hazardous Substances Data: 860-55-9(Hazardous Substances Data)

Upstream product

• 130380-55-1 N-Benzyloxycarbonyl-L-phenylalanyl-L-serin-heptylester 
• 56-45-1 L-serin 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 109453-49-8 (C₈H₇O₂)(NHCHCOO)(CH₂C₆H₅)(CO₂C₂H₅) 
• 1161-13-3 N-Cbz-L-Phe 
• 541-41-3 chloroformic acid ethyl ester 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 111061-56-4 Fmoc-Ser(Trt)-OH 
• 115054-49-4 N-benzyloxycarbonyl-L-phenylalanyl-L-(O-diphenylmethyl)-L-serine diphenylmethyl ester 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 

Downstream Products

• 118999-75-0 Z-Phe-Ser-Pro-Phe-N₂H₂-Boc 
• 118999-77-2 H-Phe-Ser-Pro-Phe-Arg(Mtr)-OH 
• 118999-76-1 Z-Phe-Ser-Pro-Phe-Arg(Mtr)-OH 
• 1380521-30-1 (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-3-(2-(((tert-butoxy)carbonyl)amino)acetoxy)propanoic acid 
• 1380521-36-7 (S)-2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-3-(2-(((tert-butoxy)carbonyl)amino)acetoxy)propanoic acid 
• 1380521-38-9 (8S,11S)-8-benzyl-11-((2-(((tert-butoxy)carbonyl)amino)acetoxy)methyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid 
• 1380521-39-0 (9S,12S)-9-benzyl-12-((((S)-2-(((benzyloxy)carbonyl)amino)propanoyl)oxy)methyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid 
• 1380521-44-7 (tert-butoxycarbonyl)glycyl-L-phenylalanyl-L-serine 
• 23828-14-0 C₁₄H₁₉N₃O₅ 
• 1380521-41-4 (tert-butoxycarbonyl)glycylglycyl-L-phenylalanyl-L-serine 
• 1380521-33-4 (S)-2-((S)-2-amino-3-phenylpropanamido)-3-(2-(((tert-butoxy)carbonyl)amino)acetoxy)propanoic acid 

Relevant articles and documents

Ecological base-conditioned preparation of dipeptides using unprotected α-amino acids containing hydrophilic side chains

The coupling reactions of 3-phenylpropanoic acid and Ncarboxybenzyl á-amino acids with unprotected á-amino acids containing hydrophilic side chains such as aliphatic alcohol, aromatic alcohol, thiol, carboxylic acid, and amide afforded the corresponding amides in 6696% yield without racemization via the corresponding mixed carbonic carboxylic anhydrides under basic conditions through an ecological green synthetic method.

Chemical ligation from O-acyl isopeptides via 8-and 11-membered cyclic transition states

Unprotected O-acylated serine and O-acylated threonine isopeptides have been synthesized, and their conversion to native tripeptides and tetrapeptides by O-to N-terminus transfer investigated. Ligations involving 8-and 11-membered cyclic transition states

Convenient peptide synthesis using unprotected α-amino acids containing another hydrophilic moiety under basic conditions

Carboxylic acids 1 and 7 reacted effectively with unprotected α-amino acids 2 containing another hydrophilic moiety under basic conditions via activation by ethyl chloroformate and triethylamine to afford the corresponding amides in 7499% yields.