860011-99-0

Basic information

• Product Name: 3-(4-chlorophenyl)-glutaric acid monoethyl ester
• Synonyms: 3-(4-chlorophenyl)-glutaric acid monoethyl ester
• CAS NO: 860011-99-0
• Molecular Weight: 270.713
• Mol File: 860011-99-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-glutaric acid monoethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-glutaric acid monoethyl ester(860011-99-0)
• EPA Substance Registry System: 3-(4-chlorophenyl)-glutaric acid monoethyl ester(860011-99-0)

Safety Data

• Hazardous Substances Data: 860011-99-0(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 35271-74-0 3-(4-chlorophenyl)pentane-1,5-dioic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 53911-68-5 3-(4-chlorophenyl)glutaric anhydride 

Downstream Products

• 5666-78-4 4-(4-chlorophenyl)tetrahydro-2H-pyran-2-one 
• 761401-08-5 3-(4-chloro-phenyl)-4-{2-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-thiazol-4-yl}-butyric acid ethyl ester 
• 722549-40-8 ethyl 6-chloro-3-(4-chlorophenyl)-5-oxohexanoate 

Relevant articles and documents

AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS

The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Enzymatic desymmetrization of 3-arylglutaric acid anhydrides

Optically active (R)- and (S)-3-arylglutaric acid monoesters 3 were synthesized in quantitative yields and good stereoselectivities by lipase-catalyzed desymmetrization of the corresponding 3-arylglutaric anhydrides 2 with alcohols. It was observed that the stereochemical outcome of the reaction was influenced by the substituents present on the aromatic ring. The influence of the enzyme, alcohol, and solvent was systematically examined. Absolute configurations of the monoesters 3 were assigned by chemical correlation to corresponding lactones 4.