86030-08-2 Usage
Description
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE is an organic compound with the molecular formula C12H8ClNO4S. It is characterized by the presence of a chloro, nitro, and phenylsulfonyl group attached to a benzene ring. 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE is known for its potential applications in various chemical and pharmaceutical processes due to its unique structural features.
Uses
Used in Chemical Synthesis:
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE is used as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and dyes. Its unique functional groups make it a versatile building block for the development of new molecules with desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE is used as a key intermediate in the synthesis of drug candidates. Its presence in the molecular structure can impart specific biological activities, making it a valuable component in the development of new therapeutic agents.
Used in Research and Development:
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE is also utilized in research and development settings to study the effects of its functional groups on the properties and reactivity of the resulting compounds. This knowledge can be applied to design and optimize new molecules with improved performance in various applications.
Used in Material Science:
In the field of material science, 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE can be used to develop novel materials with specific properties, such as improved thermal stability, chemical resistance, or optical characteristics. Its unique structure can contribute to the development of advanced materials for various industries, including electronics, aerospace, and automotive.
References
Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072
Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554
Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539
Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41
Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463
Check Digit Verification of cas no
The CAS Registry Mumber 86030-08-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,0,3 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 86030-08:
(7*8)+(6*6)+(5*0)+(4*3)+(3*0)+(2*0)+(1*8)=112
112 % 10 = 2
So 86030-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H
86030-08-2Relevant articles and documents
BTB-1 A small molecule inhibitor of the mitotic motor protein kif18A
Catarinella, Mario,Gruener, Tamara,Strittmatter, Tobias,Marx, Andreas,Mayer, Thomas U.
supporting information; experimental part, p. 9072 - 9076 (2010/03/03)
Turning the motor off: A malachite green based assay leads to the identification of BTB-1 (see picture), the first small-molecule inhibitor of the mitotic motor protein Kif18A. BTB-1 reversibly inhibits the ATPase activity of the recombinant motor domain
