86045-84-3

Upstream product

• 100-39-0 benzyl bromide 
• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 86045-82-1 4-(benzyloxy)-2,3-dihydro-1H-inden-1-one 
• 40731-98-4 4-hydroxy-2,3-dihydroindan-1-one 
• 86045-83-2 4-benzyloxyindanone tosylhydrozone 

Downstream Products

• 86045-86-5 4-benzyl-2-hydroxyoxyindyl tosylate 
• 86045-88-7 2-iodo-4-benzyloxyindan 
• 2059-92-9 7-Indenol 
• 86045-85-4 4-benzyloxyindan-2-ol 
• 1360180-22-8 C₂₀H₁₈O₂ 
• 1360180-04-6 C₂₀H₂₀O₂ 

Relevant academic research and scientific papers

Ligand Substitution of RuII–Alkylidenes to Ru(bpy)32+: Sequential Olefin Metathesis/Photoredox Catalysis

Ruthenium(II) alkylidene complexes such as the Grubbs’ 1st and 2nd generation catalysts undergo a ligand substitution with 2,2′-bipyridine, which readily leads to the common photoredox catalyst Ru(bpy)32+. The application of this catalyst transformation in sequential olefin metathesis/photoredox catalysis is demonstrated by way of ring-closing metathesis (RCM)/photoredox ATRA reactions.

TETRAHYDRONAPHTHALENE DERIVATIVE

A compound shown by general formula (I-1) (in the formula, all symbols are as stated in the specification.) has selective S1P5 receptor-binding activity. Adjusting this activity make s it possible to obtain a therapeutic agent for S1P5-mediated diseases,

NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS

Novel tricyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.

NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OSTEOPOROSIS

Novel tricyclic compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.

Directionality of Proton Transfer in Solutions. Three Systems of Known Angularity

Three compounds were synthesized each possessing rigid carbon frameworks that hold an oxygen base near a mobile C-H proton in well-defined angular and distance relationships: 2-iodo-4-hydroxyindan, endo-5-hydroxybicycloheptan-2-one, and endo-2-hydroxy-exo-6-bromomethylheptane.Effective proton transfer was detected with the second and third compounds but not the first.The data suggest that C-to-O proton transfer with severely bent O/H/C angles (106 deg) is permissible if the O-H distance is less than the sum of the van der Waals radii. "Long distance" catalysis at active sites of enzymes appears unlikely.