860603-99-2Relevant academic research and scientific papers
Copper-free asymmetric allylic alkylation using grignard reagents on bifunctional allylic bromides
Grassi, David,Alexakis, Alexandre
supporting information; experimental part, p. 1568 - 1571 (2012/06/01)
A series of substrates containing a vinylic bromide were employed in a copper-free methodology using bidendate NHC ligands. The desired compounds are generally obtained with good enantioselectivity and good regioselectivity. Importantly the copper-catalyzed system afforded a lower enantioselectivity value. The catalytic products could be transformed into a broad scope of new 1,1-disubstituted olefins in a single step transformation without erosion of the enantioselectivity.
