860642-35-9

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-BUT-3-EN-2-ONE
• Synonyms: 1-(4-FLUORO-PHENYL)-BUT-3-EN-2-ONE;1-(4-Fluorophenyl)-3-buten-2-one
• CAS NO: 860642-35-9
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• Product Categories: pharmacetical
• Mol File: 860642-35-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-BUT-3-EN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-BUT-3-EN-2-ONE(860642-35-9)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-BUT-3-EN-2-ONE(860642-35-9)

Safety Data

• Hazardous Substances Data: 860642-35-9(Hazardous Substances Data)

Usage

General Description

1-(4-Fluoro-phenyl)-but-3-en-2-one, also known as 4-fluorochalcone, is a chemical compound with the molecular formula C10H7FO. It is a yellow solid that is commonly used in the synthesis of various pharmaceuticals and organic compounds. This chemical is known for its strong odor and is often used as a flavoring agent in the food industry. It is also used in the manufacturing of dyes, perfumes, and other aromatic chemicals. Additionally, 1-(4-Fluoro-phenyl)-but-3-en-2-one has been studied for its potential biological activities, including its potential role as an anti-inflammatory and anti-cancer agent.

Upstream product

• 459-04-1 4-Fluorophenylacetyl chloride 
• 457948-95-7 2-(4-fluorophenyl)-N-methoxy-N-methylacetamide 
• 3536-96-7 vinylmagnesium chloride 
• 405-50-5 p-Fluorophenylacetic acid 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 920025-44-1 C₂₀H₃₁FO₇S₂ 
• 920025-45-2 C₃₀H₃₇F₇O₇S₂ 
• 920025-40-7 C₄₀H₆₃FO₅Si 
• 920025-41-8 C₃₄H₄₉FO₅ 
• 920025-43-0 C₁₄H₁₉FO₃ 
• 860642-36-0 tert-butyl{[1-(4-fluorobenzylidene)prop-2-en-1-yl]oxy}-dimethylsilane 

Relevant articles and documents

Organocatalytic Stereoconvergent Synthesis of α-CF3 Amides: Triketopiperazines and Their Heterocyclic Metamorphosis

The highly enantioselective alkylation of α-CF3 enolates, generated from triketopiperazines, has been accomplished through use of a bifunctional thiourea organocatalyst to facilitate 1,4-addition to varied enone acceptors. On treatment with appropriate nitrogen nucleophiles, the chiral triketopiperazine products undergo a metamorphosis, to provide novel fused heterocyclic lactams such as extended pyrazolopyrimidines.

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists

3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy} -4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]-cyclopent-2-en-1-one (17) is a high affinity, brain-penetrant, hydroisoindoline-based neurokinin-1 (NK1) receptor antagonist with a long ce

Process for making hydroisoindoline tachykinin receptor antagonists

The present invention is directed to a process for preparing certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.